不同疗程阿奇霉素联合头孢曲松治疗社区获得性肺炎患儿的效果比较  

Comparison of effects of different courses of Azithromycin combined with Ceftriaxone in the treatment of children with communityacquired pneumonia

作　　者：邵晴晓 陈余霞 SHAO Qingxiao;CHEN Yuxia(Department of Pharmacy,Children's Hospital of Soochow University,Suzhou,Jiangsu 215000,China)

机构地区：[1]苏州大学附属儿童医院药剂科,江苏苏州215000

出　　处：《医药前沿》2025年第4期44-46,50,共4页Journal of Frontiers of Medicine

摘　　要：目的比较不同疗程阿奇霉素联合头孢曲松治疗社区获得性肺炎(CAP)患儿的效果。方法选取2021年1月—2024年1月苏州大学附属儿童医院收治的80例CAP患儿,根据疗程不同分为短疗程组(n=43)和长疗程组(n=37)。两组均采用阿奇霉素联合头孢曲松治疗,短疗程组治疗5~7 d,长疗程组治疗8~14 d。治疗结束后,比较两组总有效率、症状恢复情况、血清炎症指标水平、不良反应发生情况和成本(C)-效果(E)分析结果。结果两组患儿总有效率和症状恢复情况比较,差异无统计学意义(P>0.05);短疗程组不良反应总发生率低于长疗程组(P<0.05)。治疗结束后,两组血清C反应蛋白和白细胞介素-6水平均较治疗前降低(P<0.05),但组间比较差异无统计学意义(P>0.05)。短疗程组抗生素费用和住院费用C、C/E均低于长疗程组(P<0.05);每增加1个疗效单位,抗生素费用增加85.19元,住院费用增加81.82元。结论不同疗程阿奇霉素联合头孢曲松方案治疗CAP患儿临床效果相当,短疗程组不良反应发生率和总C更低。Objective To compare the effects of different courses of Azithromycin combined with Ceftriaxone in the treatment of children with community-acquired pneumonia(CAP).Methods A total of 80 children with CAP admitted to Children's Hospital of Soochow University from January 2021 to January 2024 were selected and divided into short course group(n=43)and long course group(n=37)according to different treatment courses.Both groups were treated with Azithromycin combined with Ceftriaxone.The short course group was treated for 5-7 d,and the long course group was treated for 8-14 d.After treatment,the total effective rate,symptom recovery,serum inflammatory index level,adverse reactions and cost(C)-effectiveness(E)analysis results were compared between the two groups.Results There was no significant difference in the total effective rate and symptom recovery between the two groups(P>0.05).The total incidence of adverse reactions in the short course group was lower than that in the long course group(P<0.05).After treatment,the levels of serum C reactive protein and interleukin-6 in the two groups were lower than those before treatment(P<0.05),but there was no significant difference between the two groups(P>0.05).The C of antibiotics cost and hospitalization cost,C/E in the short course group were lower than those in the long course group(P<0.05).For each additional therapeutic unit,the cost of antibiotics increased by 85.19 yuan,and the hospitalization cost increased by 81.82 yuan.Conclusions The clinical effects of different courses of Azithromycin combined with Ceftriaxone in the treatment of children with CAP were similar,and the incidence of adverse reactions and total C were lower in the short course group.

关 键 词：社区获得性肺炎 儿童 阿奇霉素 头孢曲松 C反应蛋白 白细胞介素-6 成本-效果分析 不良反应 

分 类 号：R563[医药卫生—呼吸系统]