重组人脑利钠肽联合沙库巴曲缬沙坦治疗急性心肌梗死并发心力衰竭的临床效果  

Clinical effect of Recombinant Human Brain Natriuretic Peptide combined with Sacubitril Valsartan in the treatment of acute myocardial infarction complicated with heart failure

作　　者：宋晓 SONG Xiao(Department of Cardiovascular Medicine,Linglong Yingcheng Hospital,Zhaoyuan,Shandong 265400,China)

机构地区：[1]玲珑英诚医院心血管内科,山东招远265400

出　　处：《医药前沿》2025年第4期55-57,61,共4页Journal of Frontiers of Medicine

摘　　要：目的探讨重组人脑利钠肽(rhBNP)与沙库巴曲缬沙坦联合应用于急性心肌梗死(AMI)并发心力衰竭患者的临床疗效。方法选取2021年1月—2023年12月玲珑英诚医院收治的100例AMI并发心力衰竭患者作为研究对象,根据不同治疗方案分为观察组和对照组,各50例。对照组给予沙库巴曲缬沙坦钠片口服治疗,观察组在对照组基础上加用注射用rhBNP治疗,比较两组患者治疗效果、心功能指标水平、心肌损伤标志物水平和不良反应发生情况。结果治疗后,观察组显效率和总有效率高于对照组;两组患者每搏输出量和左心室射血分数高于治疗前,且观察组高于对照组;两组患者左心室收缩末期内径、左心室舒张末期内径、血清N末端脑钠肽前体和心肌肌钙蛋白T水平低于治疗前,且观察组低于对照组(P<0.05)。治疗期间,两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论rhBNP与沙库巴曲缬沙坦联合应用于AMI并发心力衰竭患者能够有效改善心功能,降低心肌损伤标志物水平,并提高治疗效果,且能确保患者的安全性。Objective To investigate the clinical efficacy of Recombinant Human Brain Natriuretic Peptide(rhBNP)combined with Sacubitril Valsartan in patients with acute myocardial infarction(AMI)complicated with heart failure.Methods 100 patients with heart failure complicated by AMI admitted to Linglong Yingcheng Hospital from January 2021 to December 2023 were selected as the study subjects,and they were divided into the observation group and the control group according to the different treatment plans,50 cases each.The control group received oral Sacubitril Valsartan Sodium Tablet,while the observation group received rhBNP injection along with it.The treatment effects,heart function indicators,levels of myocardial injury markers,and adverse reactions were compared between the two groups.Results After treatment,the effective rate and total effective rate were higher in the observation group than in the control group;both groups showed improved stroke volume and left ventricular ejection fraction compared to before treatment,with the observation group showing greater improvements.The left ventricular end systolic diameter,left ventricular end diastolic diameter,serum N-terminal pro-brain natriuretic peptide,and cardiac troponin T levels were lower than before treatment,and the observation group had lower levels than the control group(P<0.05).The overall incidence of adverse reactions was not significantly different between the two groups(P>0.05).Conclusions The combination of rhBNP and Sacubitril Valsartan effectively improves heart function,reduces myocardial injury markers,enhances treatment efficacy,and ensures patient safety in AMI patients with heart failure.

关 键 词：心肌梗死 心力衰竭 沙库巴曲缬沙坦 重组人脑利钠肽 每搏输出量 左心室射血分数 左心室收缩末期内径 心肌肌钙蛋白T 

分 类 号：R541[医药卫生—心血管疾病]