缩宫素联合卡前列素氨丁三醇预防高危妊娠剖宫产术后出血的临床效果  

Clinical effects of Oxytocin combined with Carboprost Tromethamine in the prevention of postoperative hemorrhage after cesarean delivery in high-risk pregnancies

作　　者：何延青 HE Yanqing(Department of Obstetrics and Gynecology,Liaocheng Shuicheng Maternity Hospital,Liaocheng,Shandong 252000,China)

机构地区：[1]聊城水城妇产医院妇产科,山东聊城252000

出　　处：《医药前沿》2025年第4期58-61,共4页Journal of Frontiers of Medicine

摘　　要：目的探讨缩宫素联合卡前列素氨丁三醇预防高危妊娠剖宫产术后出血的临床效果。方法选取2022年6月—2023年9月聊城水城妇产医院接受剖宫产的高危妊娠产妇80例,采用随机数字表法分为观察组和对照组,各40例。对照组采用缩宫素治疗,观察组在对照组基础上联合卡前列素氨丁三醇治疗。比较两组出血量、子宫收缩情况、凝血功能指标、药物止血效果、血流动力学指标及不良反应发生情况。结果观察组术中、术后2 h及术后2~24 h出血量少于对照组,用药后子宫收缩持续时间长于对照组,产后子宫下降速度快于对照组;观察组术后2 h活化部分凝血活酶时间、凝血酶时间和纤维蛋白原水平短于或低于对照组,术后24 h心率低于对照组,收缩压、舒张压、平均动脉压高于对照组(P<0.05)。两组产后出血发生率、输血率、附加止血措施干预率及不良反应总发生率比较,差异无统计学意义(P>0.05)。结论高危妊娠剖宫产产妇应用缩宫素联合卡前列素氨丁三醇可有效预防产后出血,有助于延长子宫收缩时间,减少产中与产后的出血量,改善凝血功能指标,血流动力学相对稳定,具有一定安全性。Objective To explore the clinical effect of Oxytocin combined with Carboprost Tromethamine in preventing postoperative hemorrhage after cesarean delivery in high risk pregnancies.Methods A total of 80 high-risk pregnancies who underwent cesarean delivery in Liaocheng Shuicheng Maternity Hospital from June 2022 to September 2023.They were divided into observation group and control group by random number table method,with 40 cases in each group.The control group was treated with Oxytocin,and the observation group was treated with Carboprost Tromethamine on the basis of control group,and compared the blood loss,uterine contraction status,coagulation function indicators,hemostatic effects of drug,hemodynamic parameters,and incidence of adverse reactions between the two groups.Results The observation group had less blood loss during surgery,2 h postoperation,and from 2 to 24 h postoperation compared to the control group;the duration of uterine contractions in the observation group was longer,and the uterine involution speed was faster than in the control group;the activated partial thromboplastin time,thrombin time,and fibrinogen levels were shorter or lower at 2 h postoperation in the observation group;at 24 h postoperation,the heart rate was lower,while systolic pressure,diastolic pressure,and mean arterial pressure were higher in the observation group compared to the control group(P<0.05).There were no statistically significant differences in the rates of postoperative hemorrhage,blood transfusion,additional hemostatic interventions,and total adverse reactions between the two groups(P>0.05).Conclusions The use of Oxytocin combined with Carboprost Tromethamine effectively prevents postoperative hemorrhage in high-risk pregnancies undergoing cesarean delivery,helps prolong uterine contraction time,reduces blood loss during and after the procedure,improves coagulation function markers,and maintains relative hemodynamic stability,demonstrating a certain level of safety.

关 键 词：产妇 剖宫产 高危妊娠 产后出血 缩宫素 卡前列素氨丁三醇 活化部分凝血活酶时间 心率 

分 类 号：R442[医药卫生—诊断学]