急性心梗患者PCI术后肌钙蛋白、CK-MB及B型脑钠肽水平变化的临床价值分析  

Clinical value of changes in cardiac troponin,CK-MB and brain natriuretic peptide levels in patients with acute myocardial infarction after PCI

作　　者：尹琼 张翠 席海龙 熊艳兵 Yin Qiong;Zhang Cui;Xi Hai-long;Xiong Yan-bing(Department of Laboratory Medicine,Xinyu People's Hospital,Xinyu 338000,Jiangxi,China;Department of Cardiology,Xinyu People's Hospital,Xinyu 338000,Jiangxi,China;Department of Otolaryngology,Fenyi People's Hospital,Xinyu 338000,Jiangxi,China)

机构地区：[1]新余市人民医院检验科,江西新余338000 [2]新余市人民医院心内科,江西新余338000 [3]分宜县人民医院五官科,江西新余338000

出　　处：《四川生理科学杂志》2025年第1期104-106,185,共4页

摘　　要：目的:探讨急性心肌梗死(Acute myocardial infarction,AMI)患者在接受经皮冠状动脉介入治疗(Percutaneous coronary intervention,PCI)后心肌肌钙蛋白(Cardiac troponin,cTn)、肌酸激酶同工酶(Creatine kinase-MB,CK-MB)及B型脑钠肽(Brain natriuretic peptide,BNP)水平的变化及临床价值。方法:收集2020年6月至2024年6月期间于我院就诊的82例AMI患者的临床基础资料,所有患者均进行PCI治疗,收集其基础资料。依据AMI患者在PCI手术后1 y内的恢复状况将患者划分为预后良好组54例和预后不良组28例,对比两组患者术后cTn、CK-MB及BNP水平;同时,以Logistic回归分析法探讨影响AMI患者PCI术预后的危险因素,并以Pearson分析AMI患者PCI术预后与cTn、CK-MB及BNP水平的相关性。结果:两组患者在年龄、性别、发病至入院时间、心功能、基础疾病、病变部位、PCI手术时间、吸烟史和饮酒史等方面均未发现显著的统计学差异(P>0.05)。预后不良组患者PCI术后心肌肌钙蛋白T(cardiac troponin T,cTnT)、心肌肌钙蛋白I(cardiac troponin I,cTn I)、CK-MB和BNP的浓度均高于预后良好组(P<0.05);经Logisic多因素回归Pearson相关分析示,术后cTn T、cTn I、CK-MB及BNP水平是AMI患者PCI术预后的独立危险因素,与不良预后发生风险呈正相关(P<0.05)。结论:AMI患者在PCI术后可能会出现cTn T、cTn I、CK-MB和BNP浓度的异常升高,这些生物标志物的浓度变化与AMI患者PCI术后的预后密切相关。Objective:To investigate the changes and clinical value of cTn,CK-MB and BNP levels in patients withAMI after PCI.Methods:The clinical data of 82 patients with AMI who underwent PCI in the hospital from June 2020 to June 2024 were collected.According to the recovery status within 1 year after PCI,patients enrolled were divided into favorable prognosis group(54 cases)and poor prognosis group(28 cases).Postoperative cTn,CK-MB and BNP levels in the two groups were compared.Logistic regression analysis was used to explore the risk factors influencing the prognosis of PCI in patients with AMI.Pearson analysis was used to investigate the correlation between the prognosis of PCI and the levels of cTn,CK-MB and BNP in patients with AMI.Results:There were no significant differences between the two groups in terms of age,gender,time from onset to admission,cardiac function,underlying diseases,lesion location,PCI time,smoking history,and drinking history(P>0.05).The levels of cTnI,CK-MB and BNP in the poor prognosis after PCI were higher than those in the favorable prognosis group(P<0.05).Multivariate logistic regression analysis found that postoperative levels of cTnI,CK-MB and BNP were independent risk factors influencing the prognosis of PCI in patients with AMI.Pearson correlation analysis found that the three were positively correlated with the risk of poor prognosis(P<0.05).Conclusion:There may be abnormal increases in the levels of cTnI,CK-MB and BNP in patients with AMI after PCI.Changes in the levels of these biomarkers are closely related to the prognosis of AMI after PCI.

关 键 词：急性心肌梗死 经皮冠状动脉介入治疗 肌钙蛋白 肌酸激酶同工酶MB B型脑钠肽 

分 类 号：R54[医药卫生—心血管疾病]