血清cMyBP-C、MyO、Foxo4水平在急性心肌梗死患者PCI术后的水平及与MACE发生的相关性分析  

Levels of serum cMyBP-C,MyO and Foxo4 in patients with acute myocardial infarction after PCI and their correlation with MACE

作　　者：陈海萍 Chen Hai-ping(Department of Cardiovascular Medicine,The People's Hospital of Minquan County,Minquan 476800,Henan,China)

机构地区：[1]民权县人民医院心血管内科,河南民权476800

出　　处：《四川生理科学杂志》2025年第1期149-152,共4页

摘　　要：目的:探讨急性心肌梗死(Acute myocardial infarction,AMI)患者经皮冠状动脉介入术(Percutaneous coronary intervention,PCI)术后血清心肌肌球蛋白结合蛋白-C(Myocardial myosin binding protein-C,cMyBP-C)、肌红蛋白(Myoglobin,MyO)、转录因子叉头框蛋白4(Fork head box O4,Foxo4)水平变化及其对主要不良心血管事件(Major adverse cardiovascular events,MACE)发生的预测价值。方法:选取2021年1月至2023年1月于本院接受PCI治疗的104例AMI患者进行回顾性分析。依据术后6 m是否发生MACE将患者分为发生组和未发生组。分析比较两组的血清cMyBP-C、MyO、Foxo4水平及临床资料。分析PCI术后MACE发生的影响因素。评价术后1m血清cMyBP-C、MyO、Foxo4水平对MACE发生的预测价值。结果:术后15 d、术后1m,发生组的血清cMyBP-C、MyO、Foxo4水平均明显高于未发生组(P<0.05)。Killip分级及术后1m血清cMyBP-C、MyO、Foxo4水平均为MACE发生的独立危险因素(P<0.05)。cMyBP-C、MyO、Foxo4联合检测预测MACE发生的AUC明显大于单项指标预测(P<0.05)。结论:AMI患者PCI术后血清cMyBP-C、MyO、Foxo4水平升高与MACE发生密切相关,联合检测其水平对PCI术后6 m MACE发生具有一定预测价值。Objective:To investigate the changes in serum levels of myocardial myosin binding protein-C(cMyBP-C),myoglobin(MyO),and transcription factor forkhead box O4(Foxo4)in patients with acute myocardial infarction(AMI)after undergoing percutaneous coronary intervention(PCI),and their predictive value for major adverse cardiovascular events(MACE).Methods:A retrospective analysis was conducted on 104 AMI patients who underwent PCI treatment at our hospital from January 2021 to January 2023.Patients were divided into the occurrence group and the non-occurrence group according to whether MACE occurred 6 months after surgery.The levels of serum cMyBP-C,MyO,and Foxo4,and clinical data were analyzed and compared between the two groups.The influencing factors of the occurrence of MACE after PCI were also analyzed.The predictive value of serum cMyBP-C,MyO,and Foxo4 levels for the occurrence of MACE was also evaluated at 1 month postoperatively.Results:The levels of cMyBP-C,MyO and Foxo4 in the group were significantly higher than those in the group without CMYBP-C 15 days and 1 month after surgery(P<0.05).Killip grade and serum cMyBP-C,MyO and Foxo4 levels one month after surgery were independent risk factors for MACE(P<0.05).The AUC predicted by cMyBP-C,MyO and Foxo4 combined detection was significantly higher than that predicted by single index(P<0.05).Conclusion:The increase of serum cMyBP-C,MyO and Foxo4 levels in AMI patients after PCI is closely related to the occurrence of MACE.The combined detection of CMYBP-C,MYO and FOXO4 levels has certain predictive value for the occurrence of MACE 6 months after PCI.

关 键 词：急性心肌梗死 经皮冠状动脉介入术 心肌肌球蛋白结合蛋白-C 肌红蛋白 转录因子叉头框蛋白4 

分 类 号：R542.22[医药卫生—心血管疾病]