头孢哌酮钠舒巴坦钠配合无创通气治疗对老年卧床肺部感染患者的影响  

Effect of cefoperazone sodium sulbactam sodium with non-invasive ventilation technique treatment on elderly bedridden patients with pulmonary infections

作　　者：黄招莲 陈金玲 Huang Zhao-lian;Chen Jin-ling(Department of Infectious Diseases,Jishui People's Hospital,Ji'an 331600,Jiangxi,China)

机构地区：[1]吉水县人民医院感染科,江西吉安331600

出　　处：《四川生理科学杂志》2025年第1期169-171,共3页

摘　　要：目的:探究头孢哌酮钠舒巴坦钠(Cefoperazone sodium and sulbactam sodium,CPZ-SBT)配合无创通气技术治疗对老年卧床肺部感染患者炎性因子和血气分析的影响。方法:纳入2022年1月至2024年1月收治的60例老年卧床肺部感染患者,根据随机数字表法分为联合组和对照组(n=30)。对照组进行无创通气技术治疗,持续通气4~10 h·d^(-1),联合组在对照组基础上给予CPZ-SBT,每8 h静脉滴注1次,均持续14 d。记录两组患者治疗14 d后的临床疗效;比较治疗前及治疗14 d后患者的炎症因子、血气指标[动脉血氧分压(Arterial partial pressure of oxygen,PaO_(2))、动脉血二氧化碳分压(Arterial partial pressure of carbon dioxide,PaCO_(2))、血氧饱和度(Blood oxygen saturation,SaO_(2))]及治疗安全性差异。结果:治疗后,联合组临床疗效显著高于对照组(P<0.05);两组炎症因子、PaCO_(2)水平均较治疗前降低,且联合组低于对照组(P<0.05),两组患者PaO_(2)、SaO_(2)均较治疗前升高,且联合组高于对照组(P<0.05);组间不良事件发生率差异无统计学意义(P>0.05)。结论:在老年卧床肺部感染患者中使用CPZ-SBT配合无创通气能够提高其临床疗效,控制炎性及血气指标水平。Objective:To explore the effect of cefoperazone sodium and sulbactam sodium(CPZ-SBT)combined with noninvasive ventilation on inflammatory factors and blood gas analysis in elderly patients with bedside pulmonary infection.Methods:A total of 60 elderly patients with bedridden pulmonary infection admitted from January 2022 to January 2024 were included and randomly divided into a combined group and a control group(n=30)according to a random number table method.The control group received non-invasive ventilation therapy for 4-10 hours per day,while the combined group received CPZ-SBT in addition to the control group,with intravenous infusion every 8 hours for 14 days.The clinical efficacy of the two groups of patients after 14 days of treatment was recorded.The differences in inflammatory factors,blood gas indicators,including arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2)),blood oxygen saturation(SaO_(2))and treatment safety before and after 14 days of treatment were compared.Results:After treatment,the clinical efficacy of the combined group was significantly higher than that of the control group(P<0.05);The levels of inflammatory factors and PaCO_(2) in both groups decreased compared with those before treatment,and the combined group was lower than the control group(P<0.05).The levels of PaO_(2) and SaO_(2) in both groups increased compared with those before treatment,and the combined group was higher than the control group(P<0.05).There was no significant difference in the incidence of adverse events between the groups(P>0.05).Conclusion:The use of CPZ-SBT combined with non-invasive ventilation in elderly patients with bed-ridden pulmonary infection can improve their clinical efficacy and control inflammatory and blood gas levels.

关 键 词：老年 肺部感染 头孢哌酮钠舒巴坦钠 炎性因子 血气指标 

分 类 号：R47[医药卫生—护理学]