血清N%、L%、ANG水平对老年COPD并病毒性肺炎患者重症化的预测价值研究  

Predictive value of serum N%,L%and ANG on severe exacerbation in elderly patients with COPD complicated with viral pneumonia

作　　者：高磊 Gao Lei(Department of Infection,Poyang People's Hospital,Shangrao 333100,Jiangxi,China)

机构地区：[1]鄱阳县人民医院感染科,江西上饶333100

出　　处：《四川生理科学杂志》2025年第1期180-182,共3页

摘　　要：目的:探究血清中性粒细胞百分比(Percentage of Neutrophil,N%)、淋巴细胞百分比(Percentage of lymphocyte,L%)、血管紧张素(Angiotensinogen,ANG)水平对老年慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease,COPD)并病毒性肺炎患者重症化的预测价值。方法:回顾性分析2022年3月至2024年3月鄱阳县人民医院治疗的94例老年COPD并病毒性肺炎患者的临床资料,根据患者病情严重程度分为轻症组和重症组。比较入院时两组血清N%、L%、ANG水平,分析血清N%、L%、ANG水平与病情严重程度的相关性,采用受试者工作特征曲线分析血清N%、L%、ANG水平对老年COPD并病毒性肺炎患者重症化的预测价值。结果:重症组血清N%低于轻症组(P<0.05),血清L%、ANG水平高于轻症组(P<0.05)。血清N%与老年COPD并病毒性肺炎患者病情严重程度呈负相关(P<0.05),血清L%、ANG水平与老年COPD并病毒性肺炎患者病情严重程度呈正相关(P<0.05),血清N%、L%、ANG检测的敏感度分别为86.84%、63.16%、44.74%,特异度分别为78.57%、83.93%、82.14%,其cut-off值分别为48.61%、32.60%、53.20 ng·L^(-1)。结论:血清N%、L%、ANG水平对老年COPD并病毒性肺炎患者重症化有一定预测价值,血清N%越低,血清L%、ANG水平越高,患者病情越严重,临床可结合以上指标水平变化,早期治疗及时干预,以避免病情进一步加重。Objective:To explore the predictive value of serum neutrophil percentage(N%),lymphocyte percentage(L%)and angiotensin(ANG)on severe exacerbation in elderly patients with chronic obstructive pulmonary disease(COPD)complicated with viral pneumonia.Methods:The clinical data of 94 elderly COPD patients with viral pneumonia in poyang county people's hospital were retrospectively analyzed from March 2022 to March 2024.The patients were divided into mild group and severe group according to the disease severity.Serum N%,L%and ANG at admission were compared between groups,and the correlation between serum N%,L%and ANG and disease severity was analyzed.Receiver operating characteristic curve was used to analyze the predictive value of serum N%,L%and ANG on severe exacerbation in elderly patients with COPD and viral pneumonia.Results:Serum N%in severe group was lower(P<0.05)while serum L%and ANG were higher than those in mild group(P<0.05).Serum N%was negatively correlated with disease severity in elderly patients with COPD and viral pneumonia(P<0.05),and serum L%and ANG were positively correlated with disease severity(P<0.05).The sensitivities of serum N%,L%and ANG were 86.84%,63.16%and 44.74%,and the specificities were 78.57%,83.93%and 82.14%,and the cut-off values were 48.61%,32.60%and 53.20 ng·L^(-1) respectively.Conclusion:Serum N%,L%and ANG have certain predictive value on severe exacerbation in elderly COPD patients with viral pneumonia.The lower serum N%and the higher serum L%and ANG,the more serious the disease condition.Clinically,the changes of the above indicators can be combined with early treatment and timely intervention to avoid further aggravation of disease.

关 键 词：中性粒细胞百分比 淋巴细胞百分比 血管紧张素 慢性阻塞性肺疾病 病毒性肺炎 

分 类 号：R54[医药卫生—心血管疾病]