Gold nanorods as biocompatible nano-agents for the enhanced photothermal therapy in skin disorders  

作　　者：Yamei Gao Shaohu Huo Chao Chen Shiyu Du Ruiyuan Xia Jian Liu Dandan Chen Ziyue Diao Xin Han Zhiqiang Yin 

机构地区：[1]Department of Dermatology,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China [2]Department of Pediatrics,the First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China [3]State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture,School of Medicine,Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210046,China [4]College of Engineering and Applied Sciences,State Key Laboratory of Analytical Chemistry for Life Science,Nanjing University,Nanjing,Jiangsu 210008,China

出　　处：《Journal of Biomedical Research》2025年第1期1-17,共17页生物医学研究杂志(英文版)

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.82073439 and 82373475)。

摘　　要：Rod-shaped gold nanomaterials,known as gold nanorods(GNRs),may undergo specific surface modification,because of their straightforward surface chemistry.This feature makes them appropriate for use as functional and biocompatible nano-formulations.By optimizing the absorption of longitudinally localized surface plasmon resonance in the near-infrared region,which corresponds to the near-infrared bio-tissue window,GNRs with appropriate modifications may improve the results of photothermal treatment(PTT).In dermatology,potential noninvasive uses of GNRs to enhance wound healing,manage infections,combat cutaneous malignancies,and remodel skin tissues via PTT have attracted research attention in recent years.The review discussed the basic properties of GNRs,such as their shape,size,optical performance,photothermal efficiency,and metabolism.Then,the disadvantages of using these particles in photodynamic therapy are highlighted.Next,biological applications of GNRs-based PTT are explored in detail.Finally,the limitations and future perspectives of this research are addressed,providing a comprehensive perspective on the potential GNRs with PTT.

关 键 词：gold nanorods photothermal therapy skin tumors wound healing skin infections inflammatory disease 

分 类 号：R751.05[医药卫生—皮肤病学与性病学]