Uptake of biosimilars in China:a retrospective analysis of the case of trastuzumab from 2018 to 2023  

作　　者：Qiyou Wu Zhitao Wang Yihan Fu Ren Luo Jing Sun 

机构地区：[1]School of Health Policy and Management,Chinese Academy of Medical Sciences&Peking Union Medical College,5 Dongdansantiao,Dongcheng District,Beijing,China [2]IQVIA China,8F West Tower,Huijing Twin Towers,12B Jianguomenwai Avenue,Chaoyang District,Beijing,China

出　　处：《Global Health Research and Policy》2024年第1期139-150,共12页全球健康研究与政策(英文)

基　　金：Peking Union Medical College[Fund(2019)No.22]。

摘　　要：Background The Chinese biosimilar industry has demonstrated rapid growth in recent years.Limited evidence is available about biosimilar uptake at the national level.This study aimed to assess biosimilar uptake in the case of trastuzumab and to explore potential factors influencing the biosimilar penetration at national and provincial levels.Methods This study employed an interrupted time series analysis to assess the level and trend changes of national trastuzumab originator consumption and the overall trastuzumab consumption after the price reduction of the origi-nator and the introduction of the first biosimilar using the China Hospital Pharmacy Audit procurement data from March 2018 to February 2023.A latent class trajectory model(LCTM)was also adopted to estimate the biosimilar penetration across 30 provincial-level administrative divisions(PLADs).Based on the LCTM grouping results,provincial characteristics were analyzed.Results After rapid growth,the penetration of biosimilars demonstrated a moderate ascending trend at the national level,reaching 27%in February 2023.Following the introduction of the first biosimilar in July 2021,the consumption of the originator decreased by 0.5%per month(P=0.008),and the growth rate of overall trastuzumab consumption decreased by 1.1%per month(P=0.014).LCTM fit the best when the number of trajectory classes was two,divid-ing 30 PLADs into a group demonstrating a faster increase in biosimilar penetration and the other with a slower increase.The PLADs in the fast-increasing group had a higher proportion of the population covered by the national basic health insurance,a lower proportion of the urban population,a lower proportion of the population covered by the urban employee health insurance program,a lower gross domestic product per capita,a lower total health expenditure per capita,and a lower out-of-pocket expenditure.Conclusions The uptake of trastuzumab biosimilars in China was lower compared with major European countries.The introduction of trastuzumab biosimilars pres

关 键 词：BIOSIMILARS TRASTUZUMAB Market dynamics Market competitions UPTAKE 

分 类 号：F42[经济管理—产业经济]