虹彩病毒囊膜蛋白的研究进展  

Research Progress on the Envelope Proteins of Iridovirids

作　　者：郑秦 陈建明 ZHENG Qin;CHEN Jianmin(College of Geography and Oceanography,Minjiang University,Fuzhou 350108,China)

机构地区：[1]闽江学院地理与海洋学院,福州350108

出　　处：《病毒学报》2024年第6期1486-1494,共9页Chinese Journal of Virology

基　　金：福建省自然科学基金项目(No.2022J011142),题目:虾CQIV囊膜蛋白168L介导病毒进入宿主细胞的机制研究。

摘　　要：虹彩病毒是一类含有线性双链DNA的二十面体病毒,其感染可导致水产养殖生物(如鱼类)等严重疾病。囊膜蛋白在病毒吸附、进入以及释放过程中起着关键作用,阐明囊膜蛋白的结构和功能有助于揭示虹彩病毒入侵的分子机制。本文通过对虹彩病毒囊膜蛋白的基本特征、表达、亚细胞定位、功能、相互作用以及疫苗开发等方面进行阐述,旨在为未来的研究工作提供新的思路。Iridovirids are a type of icosahedral viruses that contain linear double-stranded DNA.Infections with these viruses can lead to severe diseases in aquaculture organisms,such as fish.The envelope proteins of iridovirids play a critical role in facilitating virus attachment,entry and release.Therefore,it becomes imperative to elucidate the structure and function of these envelope proteins,to reveal the molecular mechanism behind iridovirids invasion.This review provides a summary of the research progress on the fundamental characteristics,expression pattern,subcellular localization,functional role,and interaction of the envelope proteins in iridovirids,aiming to provide new insights for future research in this field.

关 键 词：虹彩病毒 囊膜蛋白 亚细胞定位 蛋白功能 相互作用 

分 类 号：R373.9[医药卫生—病原生物学] S945.4[医药卫生—基础医学]