非洛地平缓释片联合曲美他嗪治疗老年HHD患者的疗效  

Therapeutic effect of felodipine sustained-release tablets combined with trimetazidine in the treatment of elderly patients with HHD

作　　者：郑晓辉 刘洪强 ZHENG Xiao-hui;LIU Hong-qiang(Department of Cardiology,Chongming Hospital Affiliated to Shanghai University of Medicine&Health Sciences,Shanghai,202155,China)

机构地区：[1]上海健康医学院附属崇明医院心内科,上海202155

出　　处：《心血管康复医学杂志》2025年第1期81-85,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探究老年高血压性心脏病(HHD)患者应用非洛地平缓释片联合曲美他嗪治疗对心功能、炎症因子、血压的影响。方法:纳入2020年1月-2020年12月期间上海健康医学院附属崇明医院收治的130例HHD患者,根据随机数字表法分为联合治疗组和曲美他嗪组,每组65例。曲美他嗪组采用曲美他嗪治疗,联合治疗组采用非洛地平联合曲美他嗪治疗。两组均持续治疗8周,对比两组临床疗效、心功能、炎症因子水平和血压,以及不良反应发生情况。结果:治疗8周后,与曲美他嗪组比较,联合治疗组总有效率(93.85%比76.92%)、左室射血分数(LVEF)[(51.31±8.42)%比(43.21±8.25)%]、心脏指数(CI)[(2.78±0.53)L·min^(-1)·m^(-2)比(2.39±0.49)L·min^(-1)·m^(-2)]、左心室舒张早期/晚期峰值流速(E/A)[(1.19±0.42)比(0.91±0.25)]均显著提高,收缩压(SBP)[(118.11±11.41)mmHg比(137.21±13.52)mmHg]、舒张压(DBP)[(66.21±7.22)mmHg比(76.01±8.35)mmHg]均显著降低(P均<0.01)。两组不良反应发生率无显著差异(P=1.000)。结论:HHD患者应用非洛地平与曲美他嗪联合治疗有助于改善心功能、血压,且不会增加不良反应发生风险。Objective:To investigate the effect of felodipine sustained-release tablets combined with trimetazidine on cardiac function,inflammatory factors and blood pressure in elderly patients with hypertensive heart disease(HHD).Methods:This randomized controlled study enrolled 130 HHD patients admitted in Chongming Hospital Affiliated to Shanghai University of Medicine&Health Sciences between January 2020 and December 2020.They were divided into trimetazidine group(n=65,trimetazidine therapy)and combined treatment group(n=65,additional felodipine treatment).Both groups were treated for continuous 8 weeks.Therapeutic effect,cardiac function,inflammatory factor levels,blood pressure and incidence of adverse reactions were compared between two groups.Results:After 8-week treatment,compared with patients in trimetazidine group,those in combined treatment group had significant higher total effective rate(93.85%vs.76.92%),left ventricular ejection fraction(LVEF)[(51.31±8.42)%vs.(43.21±8.25)%],cardiac index(CI)[(2.78±0.53)L·min^(-1)·m^(-2) vs.(2.39±0.49)L·min^(-1)·m^(-2)],left ventricular early-diastolic peak flow velocity/early-late peak flow velocity(E/A)[(1.19±0.42)vs.(0.91±0.25)],and significant lower systolic blood pressure(SBP)[(118.11±11.41)mmHg vs.(137.21±13.52)mmHg],diastolic blood pressure(DBP)[(66.21±7.22)mmHg vs.(76.01±8.35)mmHg](P<0.01 all).We detected no significant difference in incidence of adverse reactions between two groups(P=1.000).Conclusion:The combination of felodipine and trimetazidine in HHD patients could improve cardiac function,blood pressure without increasing risk of adverse reactions.

关 键 词：高血压 心脏病 非洛地平 曲美他嗪 

分 类 号：R544.1[医药卫生—心血管疾病]