单中心分析腹膜透析相关性腹膜炎多次发生的影响因素  

Single-center Analysis of Influencing Factors of Multiple Occurrences of Peritoneal Dialysis-related Peritonitis

作　　者：邓丽贞 陈衍强 黄佳丽 陈玉平[1] Deng Lizhen;Chen Yanqiang;Huang Jiali;Chen Yuping(Zhaoqing First People's Hospital,Zhaoqing 526020,Guangdong Province,China)

机构地区：[1]肇庆市第一人民医院,广东肇庆526020

出　　处：《中外医药研究》2025年第2期49-51,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:分析腹膜透析相关性腹膜炎多次发生的影响因素。方法:回顾性分析2021年1—12月于肇庆市第一人民医院接受腹膜透析治疗的终末期肾病患者70例的病历资料。依据腹膜炎的发生频率将患者分为两组,其中1年内发生频次≥2次的患者纳入多发组(n=18),1年内发生频次为1次的患者纳入单发组(n=52)。比较两组一般资料、实验室指标,采用Logistic回归模型分析腹膜透析相关性腹膜炎多次发生的影响因素。结果:两组性别、年龄、原发疾病、腹膜炎发生原因、用药方案及降钙素原、血钙、血磷、甲状旁腺激素、血钾、总胆固醇、甘油三酯、尿酸水平比较,差异无统计学意义(P>0.05);多发组革兰阴性菌感染率高于单发组(P<0.001);多发组超敏C反应蛋白、铁蛋白水平高于单发组,血红蛋白、血清白蛋白水平低于单发组(P<0.05)。Logistic回归分析结果显示,革兰阴性菌感染、血红蛋白及血清白蛋白水平降低是腹膜炎多次发生的危险因素(P<0.05)。结论:革兰阴性菌感染、血白蛋白及血红蛋白水平降低是导致腹膜炎多次发生的危险因素,因此,在患者腹膜透析治疗期间,临床需监测并积极纠正贫血及低蛋白血症。Objective:To analyze the influencing factors of multiple occurrences of peritoneal dialysis-related peritonitis.Methods:The medical records of 70 patients with end-stage renal disease who received peritoneal dialysis in Zhaoqing First People's Hospital from January to December 2021 were retrospectively analyzed.According to the frequency of peritonitis,the patients were divided into two groups.Patients with a frequency of≥2 times within 1 year were included in the multiple group(n=18),and patients with a frequency of 1 time within 1 year were included in the single group(n=52).The general data and laboratory indicators of the two groups were compared,and the Logistic regression model was used to analyze the influencing factors of multiple occurrences of peritoneal dialysis-related peritonitis.Results:There was no significant difference in gender,age,primary disease,cause of peritonitis,medication regimen,and levels of procalcitonin,blood calcium,blood phosphorus,parathyroid hormone,blood potassium,total cholesterol,triglyceride,and uric acid between the two groups(P>0.05).The infection rate of Gram-negative bacteria in the multiple group was higher than that in the single group(P<0.001).The levels of high-sensitivity C-reactive protein and ferritin in the multiple group were higher than those in the single group,and the levels of hemoglobin and serum albumin were lower than those in the single group(P<0.05).Logistic regression analysis showed that Gram-negative bacterial infection,decreased levels of hemoglobin and serum albumin were risk factors for multiple occurrences of peritonitis(P<0.05).Conclusion:Gram-negative bacterial infection,decreased levels of serum albumin and hemoglobin are risk factors for multiple occurrences of peritonitis.Therefore,during peritoneal dialysis treatment,anemia and hypoproteinemia should be monitored and actively corrected.

关 键 词：腹膜炎 腹膜透析 影响因素 

分 类 号：R692.5[医药卫生—泌尿科学] R572.2[医药卫生—外科学]