氯吡格雷、吲哚布芬在老年冠心病患者经皮冠状动脉介入术后的作用分析  

Effect Analysis of Clopidogrel and Indobuprofen in Elderly Patients with Coronary Heart Disease after Percutaneous Coronary Intervention

作　　者：成有为 张慧慧 潘子磊 Cheng Youwei;Zhang Huihui;Pan Zilei(Department of Cardiovascular Medicine,Xuzhou Cancer Hospital,Xuzhou 221000,Jiangsu Province,China;Department of Pharmacy,Xuzhou New Health Geriatrics Hospital,Xuzhou 221000,Jiangsu Province,China)

机构地区：[1]徐州市肿瘤医院心血管内科,江苏徐州221000 [2]徐州新健康老年病医院药剂科,江苏徐州221000

出　　处：《中外医药研究》2025年第2期58-60,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:分析老年冠心病患者经皮冠状动脉介入术(PCI)后应用吲哚布芬联合氯吡格雷治疗的临床效果。方法:选取2022年1月—2023年12月在徐州市肿瘤医院接受PCI治疗的老年冠心病患者120例,根据随机数字表法分为对照组(氯吡格雷联合阿司匹林治疗)和观察组(氯吡格雷联合吲哚布芬治疗),各60例。对比两组临床疗效、心脏功能、凝血-纤溶指标、血小板聚集率、不良反应发生率及主要不良心血管事件(MACE)发生率。结果:两组总有效率对比,无统计学差异(P>0.05)。治疗后,两组N末端脑钠肽前体、纤维蛋白原、血小板聚集率水平低于治疗前,凝血酶原时间长于治疗前,观察组N末端脑钠肽前体、纤维蛋白原水平较对照组低,凝血酶原时间较对照组长(P<0.05);治疗后,两组血小板聚集率对比,无统计学差异(P>0.05)。两组不良反应发生率对比,无统计学差异(P>0.05)。观察组MACE发生率较对照组低(P=0.027)。结论:老年冠心病患者PCI后应用氯吡格雷联合吲哚布芬治疗,可有效抑制血小板聚集,改善心脏功能、凝血-纤溶指标,减少MACE,安全性更高。Objective:To analyze the clinical effect of indobuprofen combined with clopidogrel in elderly patients with coronary heart disease after percutaneous coronary intervention(PCI).Methods:A total of one hundred and twenty elderly patients with coronary heart disease who received PCI in Xuzhou Cancer Hospital from January 2022 to December 2023 were selected and divided into control group(clopidogrel combined with aspirin)and observation group(clopidogrel combined with indobuprofen)according to random number table method,with sixty cases in each group.The clinical efficacy,cardiac function,coagulation-fibrinolysis index,platelet aggregation rate,incidence of adverse reactions and incidence of major adverse cardiovascular events(MACE)were compared between the two groups.Results:The total effective rate between the two groups had no significant difference(P>0.05).After treatment,the levels of N-terminal brain natriuretic peptide precursors,fibrinogen and platelet aggregation in two groups were lower than before treatment,prothrombin time was longer than before treatment,the levels of N-terminal brain natriuretic peptide precursor and fibrinogen in observation group were lower than those in control group,and prothrombin time was longer than that in control group(P<0.05).After treatment,the platelet aggregation rate between the two groups had no significant difference(P>0.05).The incidence of adverse reactions between the two groups had no significant difference(P>0.05).The incidence of MACE in the observation group was lower than that in the control group(P=0.027).Conclusion:After PCI,clopidogrel combined with indobuprofen can effectively inhibit platelet aggregation,improve heart function,coagulation-fibrinolysis indexes,reduce MACE,and improve safety in elderly patients with coronary heart disease.

关 键 词：氯吡格雷 吲哚布芬 老年冠心病 经皮冠状动脉介入术 

分 类 号：R541.4[医药卫生—心血管疾病]