Health-related quality of life in Thai patients with chronic hepatitis B  

作　　者：Ratthanan Chantrakul Pimsiri Sripongpun Tanawat Pattarapuntakul Naichaya Chamroonkul Chanon Kongkamol Pochamana Phisalprapa Apichat Kaewdech 

机构地区：[1]Gastroenterology and Hepatology Unit,Division of Internal Medicine,Faculty of Medicine,Prince of Songkla University,Songkhla,Thailand [2]Division of Family and Preventive Medicine,Faculty of Medicine,Prince of Songkla University,Songkhla,Thailand [3]Division of Digital Innovation and Data Analytics,Faculty of Medicine,Prince of Songkla University,Songkhla,Thailand [4]Division of Ambulatory Medicine,Department of Medicine,Faculty of Medicine Siriraj Hospital,Mahidol University,Bangkok,Thailand

出　　处：《Gastroenterology Report》2024年第1期129-135,共7页胃肠病学报道(英文)

基　　金：supported by the Faculty of Medicine,Prince of Songkla University,Songkhla,Thailand(No.63-368-14-1).

摘　　要：Background:Chronic hepatitis B(CHB)significantly impacts the health-related quality of life(HRQoL),but remains underexplored in the Thai population.Health state utilities(HSU)are indicators reflecting HRQoL which serve as fundamental inputs for economic evaluation analyses.This study aimed at assessing differences in HRQoL across five CHB stages in Thai patients,including non-cirrhotic CHB,compensated cirrhosis,decompensated cirrhosis,early-/intermediate-stage hepatocellular carcinoma(HCC)and advanced-/terminal-stage HCC.Methods:We conducted a cross-sectional study to collect HRQoL data from patients with CHB at five stages.The study included patients with CHB who were followed up at a super-tertiary care centre between March 2021 and February 2022.The participants completed the EQ-5D-5L questionnaire and provided demographic data.Disease stage and relevant data were obtained from medical records.HSU and Euroqol-visual analogue scale(EQ-VAS)scores,calculated using Thai-specific conversion coefficients,were assessed.Results:Among 422 patients,236 did not have cirrhosis,92 had compensated cirrhosis,13 had decompensated cirrhosis,55 had early-/intermediate-stage HCC,and 26 had advanced-/terminal-stage HCC.The HSU scores for non-cirrhotic,compensated cirrhosis,decompensated cirrhosis,early-/intermediate-stage HCC and advanced-/terminal-stage HCC were 0.95±0.08,0.89±0.16,0.79±0.19,0.89±0.12 and 0.52±0.39,respectively.Similarly,the EQ-VAS scores for various CHB stages were 83.56±12.90,80.48±13.03,68.76±17.40,79.00±14.38 and 62.92±20.62,respectively.A significant correlation(r=0.469,P<0.001)was observed between the HSU and EQ-VAS scores.The disease progression led to a notable HSU decline,particularly in the advanced-/terminal-stage HCC group(regression coefficient:-0.436,P<0.001).The EQ-VAS scores indicated reduced quality of life in advanced liver disease.Conclusions:Later CHB stages compromise the HRQoL.Decompensated cirrhosis and advanced-/terminal-stage HCC profoundly affect physical health and quality of

关 键 词：health state utilities chronic hepatitis B health-related quality of life EQ-5D-5L 

分 类 号：R73[医药卫生—肿瘤]