Th17细胞在自身免疫性甲状腺疾病发病机制中的研究进展  

Research progress of Th17 cells in the pathogenesis of autoimmune thyroid diseases

作　　者：孟娜[1] 高刚[1] 李瑞静 万洪磊 姚华强[3] MENG Na;GAO Gang;LI Ruijing;WAN Honglei;YAO Huaqiang(Department of Health Check,Handan First Hospital,Handan,Hebei,056000,China;Department of Urology,Handan First Hospital,Handan,Hebei,056000,China;Department of Endocrinology,Handan First Hospital,Handan,Hebei,056000,China)

机构地区：[1]邯郸市第一医院健康体检科,056000 [2]邯郸市第一医院泌尿外科,056000 [3]邯郸市第一医院内分泌科,056000

出　　处：《免疫学杂志》2024年第9期732-738,共7页Immunological Journal

摘　　要：自身免疫性甲状腺疾病是一种常见自身免疫性疾病,根据其临床表现主要分为Graves病和自身免疫性甲状腺炎,其发病机制复杂,目前仍有待探索。Th17细胞是一类炎症性细胞亚群,近年来在自身免疫性疾病中的作用备受关注。本研究旨在综述近年来发表的关于Th17细胞在Graves病和自身免疫性甲状腺炎发病机制中的作用,并阐述目前靶向Th17细胞在治疗自身免疫性甲状腺疾病中的研究进展。Autoimmune thyroid disease is one of the most common autoimmune diseases,which can be divided into Graves'disease and autoimmune thyroiditis according to its clinical manifestations.The pathogenesis is complex and remains to be explored.Th17 cells are a subset of inflammatory cells.In recent years,the role of Th17 cells in autoimmune diseases has attracted much attention.This study aims to review the role of Th17 cells in the pathogenesis of Graves'disease and autoimmune thyroiditis and elaborated the current research progress of targeting Th17 cells in the treatment of autoimmune thyroid diseases.

关 键 词：自身免疫性甲状腺疾病 TH17 TH17/TREG 发病机制 

分 类 号：R581[医药卫生—内分泌]