自拟胃安汤治疗肝胃不和型胃脘痛的疗效观察  

Observation on the therapeutic effect of self-formulated Weian decoction on patients with hepato-gastric disharmony type epigastric pain

作　　者：高翔 刘静宇 黄宗卫 GAO Xiang;LIU Jing-yu;HUANG Zong-wei

机构地区：[1]开封市中心医院中医科,河南开封475000

出　　处：《中国疗养医学》2024年第2期71-75,共5页Chinese Journal of Convalescent Medicine

基　　金：2022年度开封市科技发展计划项目(2203079)。

摘　　要：目的观察自拟胃安汤治疗胃脘痛(肝胃不和证)的临床效果及其对胃肠激素水平、免疫功能的影响。方法选取开封市中心医院2021年3月至2023年3月93例肝胃不和型胃脘痛患者作为研究对象,以随机数字表将其分为对照组46例以及观察组47例,对照组给予常规西药治疗,观察组在此基础上给予联合自拟胃安汤治疗,对比两组患者临床疗效,中医证候积分情况,胃肠激素生长抑素(SS)、胃泌素(GAS)、胃动素(MTL)水平以及免疫功能指标免疫球蛋白A(IgA)、IgG、IgM和不良反应发生情况。结果治疗后,观察组总有效率高于对照组,组间差异具有统计学意义(P<0.05);两组患者治疗后中医证候主症积分、次症积分以及总积分均较治疗前下降,且观察组积分水平均低于对照组(P<0.05);两组患者治疗后GAS水平较治疗前降低,且观察组低于对照组,SS及MTL水平均较治疗前升高,且观察组高于对照组(P<0.05);两组患者治疗后免疫球蛋白IgA、IgG、IgM水平较治疗前升高,且观察组高于对照组,组间差异具有统计学意义(P<0.05);对照组总不良反应发生率为6.52%,与观察组总不良反应发生率10.64%比较,差异无统计学意义(P>0.05)。结论“治脾胃必先调肝气”理论下自拟胃安汤联合常规西药治疗可以有效调节胃肠激素水平,减轻炎性反应,提高免疫功能,改善临床症状,且不增加不良反应发生风险,安全性较高,疗效确切。Objective To observe the therapeutic effect of self-formulated Weian decoction on patients with epigastric pain(syndrome of hepato-gastric disharmony)and its influence on gastrointestinal hormone level and immune function.Methods A total of 93 patients with hepato-gastric disharmony type epigastric pain from Kaifeng Central Hospital from March 2021 to March 2023 were selected as research objects,and were divided into a control group(46 cases)and an observation group(47 cases)based on a random number table.The control group was given conventional Western medicine treatment,and the observation group was given combined treatment with self-formulated Weian decoction on this basis.The two groups were compared in terms of the clinical efficacy,TCM syndrome scores,levels of gastrointestinal hormones somatostatin(SS),gastrin(GAS),motilin(MTL),immune function indicators immunoglobulin A(IgA),IgG,IgM and adverse reactions.Results After treatment,the total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the main symptom score,secondary symptom score and total score of TCM syndrome in both groups were decreased compared with that before treatment,and the score level in the observation group was lower than that in the control group(P<0.05).After treatment,GAS levels in both groups were lower than before treatment,and the observation group was lower than the control group.SS and MTL levels were higher than before treatment,and the observation group was higher than the control group(P<0.05).After treatment,the levels of immunoglobulin IgA,IgG and IgM in both groups were higher than before treatment,and the observation group was higher than the control group,the difference between the two groups was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the control group(6.52%)and the observation group(10.64%),P>0.05.Conclusion Under the theory of"regulating liver

关 键 词：自拟胃安汤 肝胃不和 胃脘痛 胃肠激素 免疫功能 

分 类 号：R47[医药卫生—护理学]