壳聚糖敷料促进创面愈合的研究进展  

Research progress on chitosan dressings to promote wound healing

作　　者：谭敦勇 郭嘉炜 邓志钦 刘建全[1] 赵喆[1] 李文翠[1] Tan Dunyong;Guo Jiawei;Deng Zhiqin;Liu Jianquan;Zhao Zhe;Li Wencui(Department of Hand and FootSurgery,Shenzhen Second People's Hospital(The First Hospital Affiliated to Shenzhen University),ShenzhenGuangdong,518000;Department of Medicine,Shenzhen University,Shenzhen Guangdong,518000,China)

机构地区：[1]深圳市第二人民医院(深圳大学第一附属医院)足踝外科手外科,广东深圳518000 [2]深圳大学医学部,广东深圳518000

出　　处：《生物骨科材料与临床研究》2025年第1期70-75,81,共7页Orthopaedic Biomechanics Materials and Clinical Study

基　　金：国家自然科学基金(81972085,82172465);中国高校产学研创新基金(2021JH037);广东省自然科学基金(2021A1515010706,2023A1515010102);广东省临床重点学科骨科(2000005);深圳市科技计划项目(JCYJ20190806170612680)、深圳市医学重点学科建设基金(SZXK025);深圳市科技创新委员会基础研究面上项目(JCYJ20230807115121043);中国博士后科学基金面上项目(2023M742413)。

摘　　要：皮肤是人体与外界环境之间的天然屏障。当皮肤破损时,敷料可以覆盖创面,促进愈合。壳聚糖广泛用于伤口敷料的制备,具备止血、抗菌、生物相容性好、生物降解性佳的特点,是理想的创面修复材料。笔者综述壳聚糖及其衍生物在止血、抗菌、促进愈合、减少瘢痕方面可能的作用机制,明确其作为伤口敷料的有效性及优越性。同时,笔者总结壳聚糖敷料仍存在溶解度低、机械强度差等局限性,未来的改进方向包括通过物理、化学改性改善其溶解度,以及与其他纳米材料复合增加机械强度。总之,本综述为壳聚糖在伤口敷料开发及潜在临床转化研究提供了理论参考。The skin is a natural barrier between the human body and the outside environment.When the skin is broken,dressings can cover the wound and promote healing.Chitosan is widely used in the manufacture of wound dressings and has hemostasis,antibacterial,good biocompatibility and biodegradability properties,making it an ideal wound repair material.The authors review the possible mechanisms of action of chitosan and its derivatives in hemostasis,antibacterial,healing and scarring,and clarify its efficacy and superiority as a wound dressing.At the same time,the author concludes that chitosan dressings still have the limitations of low solubility and poor mechanical strength,and future improvement directions include improving their solubility through physical and chemical modification,and compounding with other nanomaterials to increase mechanical strength.In conclusion,this review provides a theoretical reference for chitosan in wound dressing development and potential clinical translational research.

关 键 词：壳聚糖 伤口愈合 抗菌 止血 瘢痕 作用机制 

分 类 号：R318.08[医药卫生—生物医学工程]