一例大熊猫疑是癫痫病诊治与分析  

Treatment and Analysis of Suspected Epilepsy on a Giant Panda

作　　者：邓林华 杨波 王茜 魏荣平 魏明 黄山 何鸣 王承东 陈安发 任志均 凌珊珊 李德生 DENG Linhua;YANG Bo;WANG Qian;WEI Rongping;WEI Ming;HUANG Shan;HE Ming;WANG Chengdong;CHEN Anfa;REN Zhijun;LING Shanshan;LI Desheng(China Conservation and Research Centre for the Giant Panda,Key Laboratory of National Forestry and Grassland Administration on the Giant Panda,Qionglai and Minshan Mountains Conservation Biology of Endangered Wild Animals and Plants National Permanent Scientific Research Base,Chengdu,610057,China)

机构地区：[1]中国大熊猫保护研究中心,大熊猫国家林业和草原局重点实验室,邛崃山、岷山濒危野生动植物保护生物学国家长期科研基地,成都610057

出　　处：《野生动物学报》2025年第1期172-177,共6页CHINESE JOURNAL OF WILDLIFE

基　　金：中国大熊猫保护研究中心项目(CCRCGP222311);大熊猫国际合作资金项目(护动函[2021]142号)。

摘　　要：结合临床症状、CT扫描、血液常规与生化、组织病理学和应激生理学等手段对1例大熊猫(Ailuropoda melanoleuca)癫痫样病例进行回顾性分析。该个体从癫痫发作致昏迷后的第2天开始,其白细胞(WBC)、淋巴细胞(Lym)计数超出正常水平,而红细胞计数(RBC)、血红蛋白(HGB)和红细胞比容(HCT)则低于正常水平。昏迷期间的谷丙转氨酶(ALT)与钠(Na^(+)),以及昏迷后第5天的谷草转氨酶(AST)均明显高于正常水平。此外,脑组织呈现出弥漫性脑水肿、脑白质增生和坏死空洞,但CT扫描脑实质未见异常密度影;还发现癫痫发作期间的粪便皮质醇质量分数[(3207.7±994.2)ng/g]显著高于发病前[(282.4±207.3)ng/g,Z=-3.000,P=0.003],唾液皮质醇浓度也显著高于对照组个体(P<0.05)。结合医学诊断和应激生理分析,推测该个体可能是受到噪声刺激后引发机体产生急性应激,使得机体非稳态负荷过重,最终导致癫痫发作。在日常饲养管理中应以预防为主,保障动物的生活环境安静、稳定,尽量减少或避免个体受到应激源刺激,进而提高动物的生活质量。A case of epilepsy on giant panda(Ailuropoda melanoleuca)was retrospectively analyzed by clinical symptoms,CT scan,blood routine and biochemical analysis,histopathological examination and stress physiology analysis.Results showed that the white blood cell(WBC)and lymphocyte(Lym)counts exceeded normal levels,while the red blood cell(RBC),hemoglobin(HGB)and hematocrit(HCT)were lower than normal levels from the second day after the seizure and coma.The alanine aminotransferase(ALT)and sodium(Na^(+))during coma,and aspartate aminotransferase(AST)on day 5 after coma were significantly higher than normal levels.In addition,diffuse cerebral edema,white matter hyperplasia and necrotic cavities were showed on the brain tissue via histopathological examination.But CT scan of brain parenchyma did not show abnormal density shadow.Moreover,there were significant differences in fecal cortisol mass fraction before[(282.4±207.3)ng/g]and after epileptic seizure[(3207.7±994.2)ng/g,Z=-3.000,P=0.003],and salivary cortisol concentrations were significantly higher than these of the control group(P<0.05).Through various analyses of medical di⁃agnosis and stress physiology,we speculated that the panda was stimulated by noise which triggered the body to produce acute stress and lead to an overloaded allostatic load and finally led to seizure.Thus prevention should be given priority in daily feeding management.It is necessary to maintain a stable and quiet living environment,to reduce or avoid the stimula⁃tion of stressors as much as possible,so that the quality of life of animals can be improved.

关 键 词：大熊猫 癫痫 急性应激 

分 类 号：S858.9[农业科学—临床兽医学]