一氧化碳/氧气参与的端炔氧化羰基化反应  

Oxidation Carbonylation Reaction of Terminal Alkynes with Carbon Monoxide/Oxygen

作　　者：范荣 李雅婧 胡晓娜[1] 张瑞琪 刘希[1] 张东顺[1] 伊卓[1] Rong Fan;Yajing Li;Xiaona Hu;Ruiqi Zhang;Xi Liu;Dongshun Zhang;Zhuo Yi(SINOPEC(Beijing)Research Institute of Chemical Industry Co.,Ltd.,Beijing 100031,China)

机构地区：[1]中石化(北京)化工研究院有限公司,北京100013

出　　处：《化学进展》2024年第12期1944-1955,共12页Progress in Chemistry

基　　金：中国石油化工股份有限公司资助项目(No.P23232)资助。

摘　　要：氧化羰基化反应是合成含羰基化合物的重要方法,具有原料来源广及产物结构丰富等优势。近年来,随着绿色发展理念深入人心,开发以一氧化碳和氧气为原料的氧化羰基化反应成为该领域的热门方向。端炔C(sp)-H键在氧化羰基化反应中展示出优异的反应活性,能够构筑一系列不饱和羰基化合物。本综述介绍了端炔的氧化羰基化反应及其在全合成中的应用,包括氧化烷氧基羰基化、氧化胺羰基化和氧化羰基化-环化,重点阐述金属催化羰基化和金属氧化两部分的反应机理,并对该类反应的未来发展趋势予以展望。Oxidative carbonylation reactions are powerful methodologies for producing carbonyl derivatives,which show advantages such as wide source of raw materials and a diverse range of products.In recent years,with the concept of environmental protection deeply rooted,developing efficient and green oxidative carbonylation reactions with carbon monoxide and oxygen as reactants,attracts much interest in this field.The C(sp)-H bonds of terminal alkynes exhibit excellent reactivity in oxidative carbonylation reactions,which could form a series of unsaturated carbonyl compounds.This review introduces the oxidative carbonylation reactions of terminal alkynes and their applications in total synthesis,including oxidative alkoxycarbonylation,oxidative aminocarbonylation,and oxidative carbonylation-cyclization,with the focus on the reaction mechanism of carbonylation and metal oxidation.Finally,the future development trends of this field are prospected.

关 键 词：端炔 一氧化碳 氧气 氧化烷氧基羰基化 氧化胺羰基化 

分 类 号：O621.2[理学—有机化学]