不同呼吸支持在新生儿呼吸窘迫综合征治疗中的应用效果  

The Application Effect of Different Respiratory Supports in the Treatment of Neonatal Respiratory Distress Syndrome

作　　者：许瑶 夏晓芹[1] 张松青 罗荣杰 黎晓苗 XU Yao;XIA Xiaoqin;ZHANG Songqing;LUO Rongjie;LI Xiaomiao(Department of Neonatology,Dongguan Tungwah Hospital,Guangdong Dongguan 523111)

机构地区：[1]东莞东华医院新生儿科,广东东莞523111

出　　处：《深圳中西医结合杂志》2024年第22期19-23,共5页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：东莞市社会发展科技面上项目(20211800902642)。

摘　　要：目的:探讨不同呼吸支持[经鼻持续气道正压通气(NCPAP)、经鼻间歇正压通气(NIPPV)]在新生儿呼吸窘迫综合征(NRDS)治疗中的应用效果。方法:选取2023年1月至2024年6月东莞东华医院新生儿科收治的NRDS患儿80例,采用随机数字表法分为对照组和观察组,各40例,分别给予NCPAP和NIPPV治疗。比较两组患儿的血气分析、肺功能、氧化应激、炎症反应指标及并发症发生情况。结果:治疗后观察组患儿动脉血二氧化碳分压(PaCO_(2))明显低于对照组,动脉血氧分压(PaO_(2))、经皮血氧饱和度(SpO_(2))明显高于对照组,差异具有统计学意义(P<0.05)。治疗后观察组患儿呼吸频率略高于对照组,差异无统计学意义(P>0.05);吸气峰压、呼气末正压、吸入氧气浓度均明显低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组患儿血清丙二醛(MDA)水平明显低于对照组,谷胱甘肽过氧化物酶(GSH-PX)、超氧化物歧化酶(SOD)水平明显高于对照组,差异具有统计学意义(P<0.05)。治疗后观察组患儿血清白细胞介素-18(IL-18)、血清C反应蛋白(CRP)水平和白细胞计数(WBC)明显低于对照组,差异具有统计学意义(P<0.05)。观察组患儿并发症总发生率低于对照组,差异具有统计学意义(P<0.05)。结论:与NCPAP相比,NIPPV应用可明显改善NRDS患儿机体缺氧程度,患儿肺功能、机体氧化应激及炎症反应改善更为明显,且治疗期间并发症少。Objective To explore the application effect of different respiratory supports[nasal continuous positive airway pressure(NCPAP),nasal intermittent positive pressure ventilation(NIPPV)]in the treatment of neonatal respiratory distress syndrome(NRDS).Methods Eighty children with NRDS admitted to the Department of Neonatology,Dongguan Tungwah Hospital from January 2023 to June 2024 were divided into a control group and an observation group using the random number table method,with 40 cases in each group.They were treated with NCPAP and NIPPV respectively.The blood gas analysis,lung function,oxidative stress,inflammatory response indicators and incidence of complications between two groups of NRDS patients were compared.Results After treatment,the arterial partial pressure of carbon dioxide(PaCO_(2))in the observation group was significantly lower than that in the control group,while the arterial partial pressure of oxygen(PaO_(2))and transcutaneous oxygen saturation(SpO_(2))were significantly higher than those in the control group,with statistical significances(P<0.05).After treatment,the respiratory rate of the observation group was slightly higher than that of the control group,and the difference was not statistically significant(P>0.05).After treatment,the peak inspiratory pressure,positive end expiratory pressure,and inhaled oxygen concentration of the observation group were significantly lower than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the level of serum malondialdehyde(MDA)of the observation group was significantly lower than that of the control group,while the levels of serum glutathione peroxidase(GSH-PX)and superoxide dismutase(SOD)were significantly higher than those of the control group,with statistical significances(P<0.05).After treatment,the levels of serum interleukin-18(IL-18),C-reactive protein(CRP)and white blood cell count(WBC)of the observation group were significantly lower than those of the control group,and the differences were sta

关 键 词：新生儿呼吸窘迫综合征 经鼻持续气道正压通气 经鼻间歇正压通气 

分 类 号：R725.6[医药卫生—儿科]