重症自身免疫性脑炎预后与脑脊液IL-6及IL-10水平的关联分析  

A Correlation Analysis between the Prognosis of Severe Autoimmune Encephalitis and the Levels of IL-6 and IL-10 in Cerebrospinal Fluid

作　　者：唐娟娟 余朝萍 TANG Juanjuan;YU Zhaoping(Department of Neurology,People's Hospital of Pidu District,Chengdu 611730,China;Department of Cardiology,People's Hospital of Pidu District,Chengdu 611730,China)

机构地区：[1]成都市郫都区人民医院神经内科,成都611730 [2]成都市郫都区人民医院心内科,成都611730

出　　处：《临床误诊误治》2025年第4期50-54,共5页Clinical Misdiagnosis & Mistherapy

基　　金：2022年成都市医学科研课题立项项目(2022427)。

摘　　要：目的分析重症自身免疫性脑炎(AE)预后与脑脊液白细胞介素-6(IL-6)及白细胞介素-10(IL-10)水平的关联。方法选取2022年1至12月68例重症AE患者为研究对象,根据患者治疗4周后的预后情况分为预后良好组(改良Rankin量表评分<3分)38例和预后不良组(改良Rankin量表评分≥3分)30例。另外选取45例轻中症AE患者作为轻中症组。纳入患者均进行脑脊液IL-6、IL-10水平检测并比较。分析脑脊液IL-6、IL-10水平与重症AE患者预后的相关性。结果重症组脑脊液IL-6水平高于轻中症组,IL-10水平低于轻中症组(P<0.05)。预后良好组脑脊液IL-6水平低于预后不良组,IL-10水平高于预后不良组(P<0.05)。Pearson相关性分析显示,重症AE患者预后不良与脑脊液IL-6水平呈正相关(r=0.831,P<0.001),与脑脊液IL-10水平呈负相关(r=-0.755,P<0.001)。结论重症AE预后与脑脊液促炎因子IL-6及抗炎因子IL-10紧密相关,临床需注意脑脊液IL-6、IL-10水平的检测及干预,以改善患者预后。Objective To analyze the association between the prognosis of severe autoimmune encephalitis(AE)and the levels of interleukin-6(IL-6)and interleukin-10(IL-10)in cerebrospinal fluid.Methods A total of 68 patients with severe AE from January to December 2022 were selected as the research subjects.According to the prognosis at 4 weeks after treatment,the patients were divided into the good prognosis group(38 patients with improved Rankin scale score<3 points)and the poor prognosis group(30 patients with improved Rankin scale score≥3 points).In addition,45 patients with mild and moderate AE were selected as the mild and moderate group.The levels of IL-6 and IL-10 in cerebrospinal fluid were measured and compared in all patients enrolled,and the correlation between the levels of IL-6 and IL-10 in cerebrospinal fluid and the prognosis of patients with severe AE was analyzed.Results The level of IL-6 in cerebrospinal fluid in severe group was higher than that in mild and moderate group,while the level of IL-10 was lower than that in mild and moderate group(P<0.05).The level of IL-6 in the cerebrospinal fluid of the good prognosis group was lower than that of the poor prognosis group,while the level of IL-10 was higher than that of the poor prognosis group(P<0.05).Pearson correlation analysis showed that poor prognosis in severe AE patients was positively correlated with IL-6 in the cerebrospinal fluid(r=0.831,P<0.001),and negatively correlated with IL-10 in the cerebrospinal fluid(r=-0.755,P<0.001).Conclusion The prognosis of severe AE is closely related to cerebrospinal fluid pro-inflammatory factor IL-6 and anti-inflammatory factor IL-10.Clinical attention should be paid to the detection and intervention of IL-6 and IL-10 levels in the cerebrospinal fluid to improve the prognosis of patients.

关 键 词：重症自身免疫性脑炎 预后 脑脊液 促炎因子 抗炎因子 白细胞介素-6 白细胞介素-10 相关性 

分 类 号：R512.3[医药卫生—内科学]