Research progress of ischemia-free liver transplantation  

作　　者：Ming-Xi Zhang Qiang Zhao Xiao-Shun He 

机构地区：[1]Organ Transplant Center,First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510000,China [2]Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology,Guangzhou 510000,China

出　　处：《Hepatobiliary & Pancreatic Diseases International》2025年第1期18-22,共5页国际肝胆胰疾病杂志(英文版)

基　　金：supported by a grant from the Guangdong Provincial Key Laboratory of Organ Donation and Transplantation Immunity (K0230015)。

摘　　要：Ischemia-reperfusion injury (IRI) is an inherent issue in organ transplantation. Because of the allograft shortage, more and more extended criteria donor (ECD) organs are used, unfortunately these grafts are more susceptible to IRI. Although machine perfusion technology has brought hope to alleviate IRI, this technology is still unable to eradicate IRI-related organ damage. Ischemia-free liver transplantation (IFLT)can completely avoid IRI, thereby improve graft function and recipient outcome, and allow to expand organ pool. This review summarized the latest progresses in IFLT, and speculated the future development of this concept.

关 键 词：Ischemia-free liver transplantation Normothermic machine perfusion Ischemia-reperfusion injury 

分 类 号：R657.3[医药卫生—外科学]