MXene based flexible microheater for enhanced infrared imaging of cerebral blood flow  

作　　者：Qinli Ye Jinghui Lin Guoxiang Wang Shuwen Zeng Tao Jiang Xiang Gao Muhammad Danang Birowosuto Wei Xiong Chenjie Gu 

机构地区：[1]The Research Institute of Advanced Technology,Ningbo University,Ningbo,315211,Zhejiang,China [2]Department of Neurosurgery,The First Affiliate Hospital of Ningbo University,China [3]Ningbo Institute of Oceanography,Ningbo,315800,China [4]Light,Nanomaterials&Nanotechnologies(L2n),CNRS-UMR 7004,Universit e de Technologie de Troyes,10000,Troyes,France [5]Łukasiewicz Research Network-PORT Polish Center for Technology Development,Stabłowicka 147,54-066,Wrocław,Poland

出　　处：《Progress in Natural Science:Materials International》2024年第5期1021-1028,共8页自然科学进展·国际材料(英文版)

基　　金：supported by the Key Research and Development Program of Ningbo (Grant No. 2022Z134);the One health Interdisciplinary Research Project,Ningbo University (Grant No. HY202405);the K.C. Wong Magna Fund in Ningbo University

摘　　要：Infrared thermography technology is a noninvasiveness and real-time imaging method, it has attracted enormous attentions for blood flow imaging. However, the implementation of infrared thermography technology is still limited by the poor imaging quality caused by the low temperature discrimination between the target blood vessel and background. Herein, we reported a flexible and low-cost MXene based photothermal microheater for enhancing the infrared imaging of blood flow. In the experiment, MXene films with specific thickness was prepared by vacuum filtering different concentrations of MXene colloidal solutions. Thereafter, the microheaters were fabricated by assembling the MXene films on the PU tape/PDMS substrate, and then sealed with another layer of pure PDMS film on the top of MXene film. The photothermal performance of the microheaters were evaluated by using an 808-nm laser as the exciting source. Experimental results show that the optimal microheater(MXene content: 17.5 mg) can reach a safe temperature of 41.5℃ with 43.9 s under the light irradiation of100 mW·cm-2. Moreover, it can be stabilized at the equilibrium temperate for over 25 min. Finally, the above optimal microheater was used to accurately heat the simulated blood vessel. It shows that temperature difference of 3.3℃ can be induced between the heated blood vessel and environment. As a result, it significantly enhances the quality of the infrared imaging of the blood flow in the simulated vascular network.

关 键 词：MXene nanosheets MICROHEATER Infrared imaging Blood flow 

分 类 号：R318[医药卫生—生物医学工程] TN219[医药卫生—基础医学]