静注人免疫球蛋白联合万古霉素治疗小儿败血症的疗效及对血清炎性因子的影响  

Efficacy of Intravenous Immunoglobulin Combined with Vancomycin in the Treatment of Septicemia in Children And Its Influence on Inflammatory Factors in Peripheral Blood

作　　者：王潇缘 陈草明[1] 黎清虎 Wang Xiaoyuan;Chen Caoming;Li Qinghu(PICU of Zhanjiang Central People's Hospital,Zhanjiang Guangdong 524000,China)

机构地区：[1]湛江中心人民医院PICU,广东湛江524000

出　　处：《生命科学仪器》2024年第6期67-69,共3页Life Science Instruments

摘　　要：目的探究静注人免疫球蛋白与万古霉素联用对儿童败血症的治疗效果及对血清炎症指标的影响。方法选取湛江中心人民医院2022年10月至2023年10月收治的100例败血症患儿为样本,随机分为两组,对照组用万古霉素治疗,观察组在此基础上加用静注人免疫球蛋白治疗。对比两组的治疗效果、血清炎症指标[中性粒细胞与淋巴细胞比值(NLR)、降钙素原(PCT)、高敏C反应蛋白(hS-CRP)、白细胞计数(WBC)]及不良反应发生率。结果观察组疗效优于对照组,神经系统症状、体温复常时间及住院时间均比对照组短,经过治疗,观察组的CD4+、CD3+、CD4/CD8比值及IgA、IgG水平均比对照组高,观察组外周血中的NLR、PCT、hs-CRP、WBC水平均比对照组低,P<0.05。两组的不良反应发生率比较,P>0.05。结论静注人免疫球蛋白与万古霉素联合治疗儿童败血症效果显著,可有效降低炎症指标,调节患儿免疫功能,缩短恢复时间,且安全性良好。Objective:To explore the therapeutic effect of intravenous immunoglobulin combined with vancomycin on sepsis in children and its influence on serum inflammatory indexes.Methods:During the period from October 2022 to October 2023,a total of 100 pediatric patients diagnosed with septicemia were enrolled at Zhanjiang Central People's Hospital.These patients were randomly assigned into two groups for treatment comparison.The control group received vancomycin therapy,while the observation group underwent intravenous immunoglobulin treatment.The therapeutic effect,serum inflammatory indexes[neutrophil-lymphocyte ratio(NLR)、procalcitonin(PCT)、high-sensitivity C-reactive protein(hS-CRP)and white blood cell count(WBC)]and the incidence of adverse reactions were compared between the two groups.Results:The therapeutic outcome exhibited by the observation group surpasses that of the control group,and the symptoms of nervous system,the observation group exhibited shorter durations for body temperature normalization and hospitalization compared to the control group.Following treatment,the observation group showed higher levels of CD4+,CD3+,CD4/CD8 ratio,IgA,and IgG compared to the control group,and the levels of NLR、PCT、hs-CRP and WBC in the peripheral blood of the observation group are lower than those in the control group,P<0.05.The incidence of adverse reactions between the two groups was compared,P>0.05.Conclusion:Intravenous injection of human immunoglobulin combined with vancomycin in the treatment of septicemia in children is effective,which can effectively reduce the inflammatory index,regulate the immune function of children,shorten the recovery time and have good safety.

关 键 词：小儿败血症 静注人免疫球蛋白 万古霉素 炎症指标 免疫功能 

分 类 号：R985[医药卫生—药品]