髓源性抑制细胞对寄生虫感染的免疫调控作用研究进展  

Research progress on the immune regulatory effect of myeloid derived suppressor cells on parasitic infections

作　　者：熊海婷 周必英 Xiong Haiting;Zhou Biying(Department of Parasitology,Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]贵州省遵义医科大学寄生虫学教研室,遵义563000

出　　处：《中华地方病学杂志》2024年第11期937-941,共5页Chinese Journal of Endemiology

基　　金：国家自然科学基金(82460402、81960378)

摘　　要：髓源性抑制细胞(MDSC)是一类来源于骨髓的未成熟分化的异质性细胞。MDSC在寄生虫感染中具有双重作用。该细胞一方面可通过诱导宿主分泌γ-干扰素(IFN-γ)、白细胞介素(IL)-4和IL-13等诱导辅助性T细胞1/2(Th1/Th2)型免疫应答,另一方面还可分泌IL-10、IL-17、转化生长因子-β(TGF-β)诱导调节性T细胞(Treg)/Th17型免疫应答,从而发挥免疫保护或免疫逃逸作用。本文就MDSC在寄生虫感染中对宿主T细胞免疫调控的研究进展作一综述。Myeloid derived suppressor cells(MDSCs)are a type of immature,differentiated,heterogeneous cells derived from the bone marrow.MDSC plays a dual role in parasitic infections.On the one hand,the cells can induce helper T cell 1/2(Th1/Th2)immune responses by inducing host secretion of interferon-γ(IFN-γ),interleukin(IL)-4,and IL-13.On the other hand,they can also secrete IL-10,IL-17 and transforming growth factor-β(TGF-β)to induce regulatory T cells(Treg)/Th17 immune responses,thereby exerting immune protection or immune escape.This article provides a review of the research progress on the immune regulation of host T cells by MDSC in parasitic infections.

关 键 词：寄生虫 髓源性抑制细胞 T细胞 免疫调控 

分 类 号：R392.9[医药卫生—免疫学] R392[医药卫生—基础医学]