甘油三酯-葡萄糖指数与社区人群颈动脉斑块的相关性分析  

Association between triglyceride glucose index and carotid plaque in community dwelling population

作　　者：邹朝双 姜迪 耿洋洋 邹朝平 王长超 范胜强 ZOU Chaoshuang;JIANG Di;GENG Yangyang;ZOU Chaoping;WANG Changchao;FAN Shengqiang(Occupational and Environmental Health Monitoring Department,Center for Disease Control and Prevention,Dezhou 253100,China)

机构地区：[1]德州市疾病预防控制中心职业与环境卫生监测科,山东省德州市253100 [2]山东大学齐鲁医院德州医院神经外科 [3]山东大学齐鲁医院德州医院医学检验科 [4]山东大学齐鲁医院德州医院健康体检中心

出　　处：《中国煤炭工业医学杂志》2024年第5期534-540,共7页Chinese Journal of Coal Industry Medicine

基　　金：山东省中医药科技项目(编号:M-2022114)

摘　　要：目的 探讨社区查体人群中甘油三酯-葡萄糖(TyG)指数与颈动脉斑块(CP)的相关性,为社区人群颈动脉斑块的预防控制提供参考依据。方法 回顾性分析2021年1月—2023年8月在山东大学齐鲁医院德州医院行健康查体的社区人群的临床资料,筛查出有完整颈部动脉彩超诊断并检查资料完善的人群,根据是否有颈动脉斑块分为阳性组和阴性组,通过多因素logistic分析TyG指数及其四分位数(TyGQ1、TyGQ2、TyGQ3、TyGQ4)与颈动脉斑块关联性,采用曲线拟合分析TyG指数与颈动脉斑块的线性关系;通过调整性别、年龄、BMI进行亚组分析,明确不同亚组是否存在交互作用;绘制受试者工作特征曲线(ROC)评价TyG指数对社区人群颈动脉斑块的预测价值。结果 共入选12 024人,平均年龄(50.3±11.3)岁,男性8 031人(66.8%),TyG指数与颈动脉斑块形成风险有相关性OR为1.15(95%CI:1.06~1.24);将Ty G指数采用四分位数分类,以Ty GQ1为参照组,在构建的3个模型中TyGQ2、TyGQ3、TyGQ4均与颈动脉斑块相关,差异有统计学意义(均P<0.05);回归趋势性检验差异有统计学意义(P<0.05)。曲线拟合分析显示Ty G指数与颈动脉斑块形成存在线性关联(P>0.05);进一步亚组分析结果显示各亚组间无交互作用(P>0.05);ROC曲线分析结果显示,TyG指数预测社区人群颈动脉斑块的AUC为0.576(95%CI:0.565~0.586)(P<0.001);TyG指数的截断值为8.5,敏感度为71.4%,特异度为40.5%。结论 TyG指数和颈动脉斑块形成呈线性相关,对社区人群颈动脉斑块有预测价值,TyG指数可能成为早期预测颈动脉斑块形成的参考指标。Objective To explore the correlation between the triglyceride-glucose(TyG)index and carotid plaque(CP)in the community population undergoing physical examinations.Methods A retrospective analysis was conducted on the clinical data of the community population who underwent health check-ups at our center from January 2021 to August 2023.Individuals with complete carotid artery color Doppler ultrasound diagnostic and examination data were screened.The population was divided into positive and negative groups based on the presence of carotid plaques,and the correlation between TyG index and its quartiles(TyGQ1,TyGQ2,TyGQ3,TyGQ4)with carotid plaques was analyzed using multiple logistic regression.The linear relationship between TyG index and carotid plaques was analyzed using curve fitting.Subgroup analyses were conducted by adjusting for gender,age,and BMI to determine if there was an interaction between different subgroups.The predictive value of TyG index for carotid plaques in the community population was evaluated using receiver operating characteristic(ROC)curve analysis.Results A total of 12024 individuals were included,with a mean age of(50.3±11.3)years.There was a correlation between TyG index and the risk of carotid plaque formation(OR=1.15,95%CI:1.06-1.24).When TyG index was categorized into quartiles,TyGQ2,TyGQ3,and TyGQ4 were all significantly associated with carotid plaques(P<0.05).The regression trend test showed P<0.05.Curve fitting analysis indicated a linear relationship between TyG index and carotid plaques(P>0.05).Subgroup analysis revealed no interaction between different subgroups(P>0.05).ROC curve analysis showed an AUC of 0.576(95%CI:0.565-0.586),P<0.001,for the prediction of carotid plaques in the community population by TyG index,with a cut-off value of 8.5,sensitivity of 71.4%,and specificity of 40.5%.Conclusion TyG index is linearly correlated with carotid plaque formation and has predictive value for carotid plaques in the community population.TyG index may serve as a reference index for e

关 键 词：甘油三酯-葡萄糖指数 颈动脉斑块 相关性分析 

分 类 号：R542.2[医药卫生—心血管疾病]