疏风解毒胶囊对神经梅毒患者T淋巴细胞亚群、梅毒螺旋体明胶凝聚试验率影响研究  

Study on the effect of Shufeng Jiedu Capsules on T lymphocyte subsets and Treponema pallidum gelatin coagulation test rate in patients with neurosyphilis

作　　者：徐丰 吴园琴 XU Feng;WU Yuanqin(Department of Dermatological,Suzhou hospital of combination of Chinese traditional and western medicine,Suzhou 215101,China)

机构地区：[1]江苏省苏州市中西医结合医院皮肤科,215101

出　　处：《中国煤炭工业医学杂志》2024年第5期482-486,共5页Chinese Journal of Coal Industry Medicine

基　　金：江苏省卫生健康委2021年度医学科研立项项目(编号:ZD20210010)

摘　　要：目的 分析疏风解毒胶囊治疗神经梅毒的临床效果及T淋巴细胞亚群、梅毒螺旋体明胶凝聚试验(TPPA)转阴率影响。方法 按照病例对照研究设计,采用优效性检验计算样本量,选择苏州市中西医结合医院2020年10月—2023年10月就诊的112例神经梅毒患者,根据治疗方法的不同将其分为基础组和观察组,各56例,基础组给予青霉素G钠治疗,观察组在基础组基础上给予疏风解毒胶囊治疗,比较两组脑脊液快速血浆反应(RPR)滴度、血清RPR滴度、觉词汇学习测试(AVLT)评分、语言流畅性测验(VFT)评分、简易智力状态检查量表(MMSE)评分、T淋巴细胞亚群指标、TPPA转阴率、不良反应总发生率。结果 观察组、基础组性别、年龄、病程、发病形式、BMI等基线资料相比,差异无统计学意义(P>0.05)。观察组治疗后脑脊液RPR滴度、血清RPR滴度、CD8^(+)均较基础组更低,差异有统计学意义(P<0.05)。观察组治疗后AVLT评分、VFT评分、MMSE评分、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均较基础组更高,差异有统计学意义(P<0.05)。观察组TPPA转阴率(83.93%)较基础组(62.50%)更高,差异有统计学意义(P<0.05)。观察组不良反应总发生率(8.93%)与基础组(5.36%)比较,差异无统计学意义(P>0.05)。结论 疏风解毒胶囊可有效提高神经梅毒TPPA转阴率,改善临床症状,降低RPR滴度,调节T淋巴细胞亚群失衡现象,且未引发严重不良反应,安全有效。Objective Analysis of the clinical efficacy of Shufeng Jiedu Capsules in the treatment of neurosyphilis and the influence of T lymphocyte subsets and Treponema pallidum particle agglutination test(TPPA)negative conversion rate.Methods According to the case-control study design,a superiority test was used to calculate the sample size.112 neurosyphilis patients who visited our hospital from October 2020 to October 2023 were selected and divided into two groups of 56 patients each based on different treatment methods.The basic group was treated with penicillin G sodium,while the observation group was treated with Shufeng Jiedu capsules on top of the basic group.The rapid plasma reaction(RPR)titers of cerebrospinal fluid,serum RPR titers,auditory verbal learning test(AVLT)scores,verbal fluency test(VFT)scores,mini mental state examination(MMSE)scores of the two groups were compared.Score,T lymphocyte subset indicators,TPPA conversion rate,and overall incidence of adverse reactions.Results There was no statistically significant difference(P>0.05)in baseline data such as gender,age,disease duration,onset form,and BMI between the observation group and the baseline group.After treatment,the cerebrospinal fluid RPR titer,serum RPR titer,and CD8+in the observation group were lower than those in the baseline group,and the difference was statistically significant(P<0.05).After treatment,the AVLT score,VFT score,MMSE score,CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in the observation group were higher than those in the baseline group,and the differences were statistically significant(P<0.05).The TPPA conversion rate in the observation group(83.93%)was higher than that in the baseline group(62.50%),and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the observation group(8.93%)was not significantly different from that in the baseline group(5.36%)(P>0.05).Conclusion ShufengJiedu capsule can effectively improve the negative rate of TPPA in neurosyphilis,improve clinical symptoms,reduce RP

关 键 词：青霉素G钠 疏风解毒胶囊 神经梅毒 T淋巴细胞亚群 

分 类 号：R542.2[医药卫生—心血管疾病]