肠道菌群在多囊卵巢综合征中的作用机制  

The Role of Gut Microbiota in Patients with Polycystic Ovary Syndrome

作　　者：石百超 常惠[2] 王宇[2] 卢凤娟 王凯悦 关木馨 马良 吴效科(审校)[2] SHI Bai-chao;CHANG Hui;WANG Yu;LU Feng-juan;WANG Kai-yue;GUAN Mu-xin;MA Liang;WU Xiao-ke(Graduate School of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of Gynecology,First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学研究生院,哈尔滨150040 [2]黑龙江中医药大学附属第一医院妇科,哈尔滨150040

出　　处：《国际生殖健康/计划生育杂志》2024年第3期238-243,共6页Journal of International Reproductive Health/Family Planning

基　　金：黑龙江省“头雁”团队-中西医结合妇科特色技术创新团队;2023年中医药循证能力提升项目;徐州市临床医学创新团队A类项目(2019TD005)

摘　　要：肠道微生物群是存在于人体肠道且含量丰富的微生物,通过神经、内分泌等多种途径影响机体生命活动,进而参与许多疾病过程。多囊卵巢综合征(polycystic ovary syndrome,PCOS)是育龄期女性最常见的内分泌疾病之一。肠道菌群可能是PCOS发展的潜在致病因素,其组成改变与胰岛素抵抗、高雄激素血症、慢性炎症和肥胖等临床特征相关。同样,胆汁酸和短链脂肪酸等肠道菌群代谢产物参与PCOS病理过程。在这种情况下,应用粪菌移植、益生菌、益生元和合生元制剂,以及生物碱、黄酮类和多酚等天然产物能够改变肠道菌群组成和代谢产物水平,并且通过调节肠道菌群功能来改善PCOS的内分泌和代谢紊乱。鉴于此,对近几年肠道菌群研究进行综述,以期为临床治疗PCOS提供参考。Gastrointestinal microbiome is a rich collection of microorganisms that exist in the human intestine,which affects the life activities of the body via various pathways such as nerve,endocrine,and participates in the process of many diseases.Polycystic ovary syndrome(PCOS)is one of the most common endocrine disorders in reproductive-aged women.Gastrointestinal microbiome may be a potential pathogenic factor for the development of PCOS,and the change of its composition is correlated with clinical features such as insulin resistance,hyperandrogenism,chronic inflammation and obesity.Similarly,the metabolites of gastrointestinal microbiome such as bile acids and short-chain fatty acids are involved in the pathological process of PCOS.In this context,the agents of fecal microbiota transplantation,probiotics,prebiotics and synbiotics,as well as the natural products including alkaloids,flavonoids and polyphenols,can change the composition of gastrointestinal microbiome and the level of metabolites,and regulate the function of gastrointestinal microbiome to improve the endocrine and metabolic diseases of PCOS.Therefore,the research progress on gastrointestinal microbiome is reviewed in order to provide a reference for clinical therapeutic approaches of PCOS.

关 键 词：多囊卵巢综合征 胃肠道微生物组 代谢 治疗 

分 类 号：R711.75[医药卫生—妇产科学]