miR-202在生殖调控中的研究进展  

Advancements of MiR-202 in Reproductive Modulation

作　　者：梁越 董杰 肖西峰 王晓红(审校) LIANG Yue;DONG Jie;XIAO Xi-feng;WANG Xiao-hong(Reproductive Medicine Center,Tangdu Hospital,Air Force Medical University,Xi′an 710000,China)

机构地区：[1]空军军医大学唐都医院生殖医学中心,西安710000

出　　处：《国际生殖健康/计划生育杂志》2024年第3期228-233,共6页Journal of International Reproductive Health/Family Planning

基　　金：国家自然科学基金(82271734,82101794)

摘　　要：微小RNA(microRNA,miRNA)可调控细胞的增殖、分化、凋亡和代谢等生物过程,参与生物的生殖发育过程。作为let-7家族的一员,miR-202具有高度保守的碱基序列,提示miR-202在不同物种中的功能和调控作用可能相似。其可参与多种机体的病理生理过程,如减缓肿瘤细胞的增殖、迁移和侵袭,调控T细胞分化,参与调控神经发育和神经退行性疾病。还可参与配子的发生与成熟,调控生殖生理过程。综述miR-202在精子发生、卵泡发育及生殖内分泌中的调控作用。MicroRNAs(miRNAs)have emerged as key regulators of diverse biological processes,including cell proliferation,differentiation,apoptosis,and metabolism.They are also actively involved in the reproductive and developmental processes of organisms.Among the let-7 family,miR-202 stands out owing to its high conservation across different species,implying the potential shared functions and regulatory roles.Substantial evidence from numerous studies underscores the involvement of miR-202 in a wide range of pathophysiological processes.Notably,it exerts significant inhibitory effects on tumor cell proliferation,migration,and invasion.Moreover,miR-202 plays a critical role in modulating the differentiation of T cell and exhibits the implications in the regulation of neurodevelopment and neurodegenerative diseases.The increasing evidence have indicated that miR-202 plays a crucial role in gamete development and the regulation of reproductive physiology.In this article,we review the regulatory roles of miR-202 in key reproductive processes,namely spermatogenesis,follicle development,and reproductive endocrine regulation.

关 键 词：微RNAS 精子发生 性分化 生殖细胞 微小RNA-202 生殖调控 

分 类 号：R339.2[医药卫生—人体生理学]