益肾健骨法联合骨折端血肿回植对四肢骨折患者骨折愈合及血清骨转化标志物表达的影响  

Effects of Invigorating Kidney and Strengthening Bones Method Combined with Fracture End Hematoma Replantation on Fracture Healing and Serum Bone Turnover Marker Expression in Patients with Extremity Fractures

作　　者：单清洁 杨士翔 岳周 SHAN Qingjie;YANG Shixiang;YUE Zhou(Department of Orthopaedics,Taihe Hospital of Traditional Chinese Medicine Affiliated to Anhui University of Chinese Medicine,Taihe 236600,Anhui,China)

机构地区：[1]安徽中医院大学附属太和中医院骨一科,安徽太和236600

出　　处：《辽宁中医杂志》2024年第5期139-143,共5页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的 探究益肾健骨法联合骨折端血肿回植对四肢骨折患者骨折愈合及血清骨转化标志物表达的影响。方法 选取2020年1月—2022年6月该院收治的123例患者作为研究对象,按照随机数字表法分为对照1组、对照2组、研究组,各41例。对照1组采用骨折端血肿回植治疗,对照2组采用益肾健骨法治疗,研究组采用益肾健骨法联合骨折端血肿回植治疗。比较3组疗效、骨折愈合、肿胀消除、住院时间、术前、术后1个月中医证候积分、炎症因子[肿瘤坏死因子-α(TNF-α)、血管细胞黏附分子(sVCAM-1)、可溶性细胞间黏附分子(sICAM-1)]、血清骨转化标志物[1型前胶原氨基末端前肽(P1NP)、骨钙素N端中分子片段(NMID)、骨特异碱性磷酸酶(BSAP)、β-胶原降解产物(β-CTX)],以酶联免疫吸附法测定血清NMID、BSAP水平。结果 研究组总有效率较对照1组、对照2组高(P<0.05);研究组骨折愈合、肿胀消除、住院时间较对照1组、对照2组短,对照2组肿胀消除时间较对照1组短(P<0.05);术后1个月研究组中医证候积分较对照1组、对照2组低(P<0.05);术后1个月研究组血清TNF-α、sVCAM-1、sICAM-1水平较对照1组、对照2组低(P<0.05);术后1个月研究组血清P1NP、β-CTX较对照1组、对照2组低,NMID、BSAP较对照1组、对照2组高(P<0.05)。结论 益肾健骨法联合骨折端血肿回植治疗四肢骨折患者效果显著,可有效促使症状改善,促进骨转化标志物改善与骨折愈合,降低炎症因子水平,加快康复进程。Objective To explore the effects of invigorating kidney and strengthening bones method combined with hematoma replantation on fracture healing and expressions of serum bone transformation markers in patients with limb fracture.Methods A total of 123 patients admitted to the hospital from January 2020 to June 2022 were selected as research objects and divided into control group 1,control group 2 and study group according to random number table method,with 41 cases in each group.Control group 1 was treated with hematoma replantation at fracture end,control group 2 was treated with invigorating kidney and strengthening bones method,and the study group was treated with invigorating kidney and strengthening bones method combined with hematoma replantation at fracture end.The efficacy,fracture healing,swelling reduction,length of hospital stay,TCM syndrome scores before and one month after surgery,inflammatory factors[tumor necrosis factor-α(TNF-α),vascular cell adhesion molecule(sVCAM-1),soluble intercellular adhesion molecule(sICAM-1)],serum markers of bone transformation[amino terminal propeptide of type 1 procollagen(P1NP),osteocalcin N-terminal molecular fragment(NMID),bone specific alkaline phosphatase(BSAP),β-collagen degradation product(β-CTX)]were compared among the three groups by enzyme-related immunosorbent assay.Results The total effective rate of the study group was higher than that of control group 1 and control group 2(P<0.05).Fracture healing,swelling elimination and hospital stay in the study group were shorter than those in control group 1 and control group 2,and the swelling elimination time in control group 2 was shorter than that in control group 1(P<0.05).One month after surgery,the TCM syndrome score of the study group was lower than that of control group 1 and control group 2(P<0.05).The serum levels of TNF-α,sVCAM-1 and sICAM-1 in the study group were lower than those in control group 1 and control group 2 one month after operation(P<0.05).One month after operation,the serum levels of P1N

关 键 词：益肾健骨法 骨转化标志物 四肢骨折 骨折端血肿回植 骨折愈合 

分 类 号：R274.1[医药卫生—中医骨伤科学]