参萸顿咳方结合益生菌治疗小儿百日咳效果研究  

Effect of Shenyu Dunke Decoction(参萸顿咳方)Combined with Probiotics on Pertussis in Children

作　　者：张艳文 李春梅 刘振奎[1] 卢艳辉[1] 高娇娇 曹燕玲 许丽菲 ZHANG Yanwen;LI Chunmei;LIU Zhenkui;LU Yanhui;GAO Jiaojiao;CAO Yanling;XU Lifei(Pediatric Internal Medicine,The First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,Hebei,China)

机构地区：[1]河北北方学院附属第一医院儿科,河北张家口075000

出　　处：《辽宁中医杂志》2024年第5期87-90,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：河北省卫生健康委员会青年科技基金项目(20211012)

摘　　要：目的 观察参萸顿咳方结合益生菌辅助治疗小儿百日咳临床效果。方法 将该院儿科收治的98例百日咳患儿(2019年4月—2022年4月)纳入该次试验研究,并以随机数字表法将患儿分为对照组(49例)与观察组(49例)两组,对照组患儿益生菌(双歧杆菌四联活菌片)治疗,观察组患儿在对照组治疗基础上结合参萸顿咳方治疗,数据观察:临床疗效、肺部啰音消失时间及痉咳改善时间、治疗前后中医证候积分(咳嗽、面色青灰、眼睑浮肿、鼻衄舌红、舌下生疮等)变化、血清肠黏膜屏障相关因子乳脂球表皮生长因子-8(MFG-E8)及D-乳酸(D-LA)水平变化、免疫球蛋白(IgA、IgG、IgM)指标变化、不良反应。结果 观察组患儿治疗总有效率(95.92%,47/49)比对照组患儿(83.67%,41/49)更高,差异有统计学意义(P<0.05);观察组患儿经治疗后肺部啰音消失时间及痉咳改善时间均比对照组患儿短,差异有统计学意义(P<0.05);两组患儿治疗前中医证候积分(咳嗽、面色青灰及眼睑浮肿、鼻衄舌红、舌下生疮等)、MFG-E8及D-LA水平、IgA、IgG、IgM等指标比较,P>0.05,治疗后各组患者中医证候积分(咳嗽、面色青灰、眼睑浮肿、鼻衄舌红、舌下生疮等)、MFG-E8及D-LA水平、IgA、IgG、IgM均好转,治疗后观察组患儿中医证候积分(咳嗽、面色青灰及眼睑浮肿、鼻衄舌红、舌下生疮等)、MFG-E8及D-LA水平、IgA、IgG、IgM等指标优于对照组,P<0.05;两组患儿均未见严重肝肾功能异常等不良反应。结论 参萸顿咳方结合益生菌辅助治疗治疗小儿百日咳效果显著,可较好促进患儿肠道功能,提升患儿免疫功能,患儿症状改善,恢复快,且安全可靠,值得应用。Objective To observe the clinical effect of Shenyu Dunke Decoction(参萸顿咳方)combined with probiotics in the adjuvant treatment of pertussis in children.Methods A total of 98 children with pertussis admitted to the hospital from April 2019 to April 2022 were included in this study,and the children were divided into control group(49 cases)and observation group(49 cases)by random number table method.The control group was treated with probiotics(bifidobacteria quadruple viable tablets).On the basis of treatment in the control group,the children in the observation group were treated with Shenyu Dunke Decoction.The clinical efficacy,disappearance time of lung rales and improvement time of spasmodic cough,changes in traditional Chinese medicine syndrome scores(cough,pale complexion,eyelid swelling,nosebleeds,redness of the tongue,and sublingual sores,etc.)before and after treatment,the serum intestinal mucosal barrier related factors such as milk fat globule-EGF factor 8(MFG-E8)and D-lactate levels,changes in immunoglobulin(IgA,IgG,IgM)indicators and adverse reactions were observed.Results The total effective rate in the observation group(95.92%,47/49)was higher than that in the control group(83.67%,41/49)(P<0.05).The disappearance time of pulmonary rales and the improvement time of spasmodic cough in the observation group were shorter than those in the control group(P<0.05).Comparison of TCM syndrome scores(cough,pale face and swelling of eyelid,epistaxis red,sublingual ulcer,etc.),the levels of MFG-E8 and D-LA level,IgA,IgG,IgM and other indicators between the two groups before treatment had no significance(P>0.05).After treatment,TCM syndrome scores(cough,pale complexion,eyelid swelling,nosebleeds,redness of the tongue,and sublingual sores,etc.),MFG-E8 and D-LA levels,IgA,IgG and IgM of patients in each group improved and those in the observation group were better than those in the control group(P<0.05).There were no serious adverse reactions such as abnormal liver or kidney function in both groups.Conclusion

关 键 词：小儿百日咳 参萸顿咳方 益生菌 疗效 肠道功能 

分 类 号：R272.5[医药卫生—中医儿科学]