降尿酸方辅助治疗痛风伴高尿酸血症的临床疗效及对血清IL-1β、IL-6的影响  

Clinical Effect of Jiangniaosuan Prescription(降尿酸方)in Adjuvant Treatment of Gout Accompanied by Hyperuricemia and Its Effect on Serum IL-1βand IL-6

作　　者：王骆冰[1] 吴锋[1] 姚东升[1] 兰天鹰 高建东[1] WANG Luobing;WU Feng;YAO Dongsheng;LAN Tianying;GAO Jiandong(Department of Nephrology,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Institute of Traditional Chinese Medicine and Kidney Diseases,Key Laboratory of Liver and Kidney Diseases,Ministry of Education(Shanghai University of Traditional Chinese Medicine),Shanghai Key Laboratory of Traditional Chinese Medicine,Shanghai 200335,China)

机构地区：[1]上海中医药大学附属曙光医院肾病科,上海中医药大学中医肾病研究所,肝肾疾病病证教育部重点实验室(上海中医药大学),上海市中医临床重点实验室,上海200335

出　　处：《辽宁中医杂志》2024年第5期76-79,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81874437);上海市第二批中医专科(专病)联盟建设项目-肾水病中医专病联盟建设项目(ZY[2021-2023]-0302)

摘　　要：目的 探究降尿酸方辅助治疗痛风伴高尿酸血症的临床疗效及对血清白细胞介素-6(interleukin-6,IL-6)、白细胞介素-1β(interleukin-1β,IL-1β)的影响。方法 以2021年1月—2021年12月该院收治的80例痛风伴高尿酸血症患者为研究对象,依据随机数字表分入观察组40例和对照组40例。对照组给予非布司他片口服,观察组在对照组基础上加用降尿酸方辅助治疗。比较两组治疗疗效、不良反应及治疗前后痰浊阻滞证中医证候积分、血尿酸水平、血清炎性因子变化情况。结果 与对照组(80.00%,32/40)相比,观察组治疗总有效率(95.00%,38/40)更高(P<0.05);两组治疗后关节肿胀、局部酸麻疼痛、目眩、面浮足肿、胸脘痞闷等中医证候较治疗前均降低,且观察组中医证候积分均低于对照组,差异有统计学意义(P<0.05);两组治疗后血尿酸、血清IL-6、IL-1β、肿瘤坏死因子-α(TNF-α)水平较治疗前均降低,且观察组低于对照组,差异有统计学意义(P<0.05);观察组与对照组不良反应[15.00%(6/40) vs 10.00%(4/40)]比较差异无统计学意义(P>0.05)。结论 降尿酸方辅助治疗痛风伴高尿酸血症疗效确切,可降低患者中医证候积分,降低血尿酸及血清IL-6、IL-1β水平,改善机体炎症反应,值得临床推广应用。Objective To explore the clinical effect of Jiangniaosuan Prescription(降尿酸方)in adjuvant treatment of gout accompanied by hyperuricemia and its effect on serum interleukin-1β(IL-1β)and interleukin-6(IL-6).Methods A total of 80 patients with gout and hyperuricemia admitted to the hospital from January 2021 to December 2021 were selected as research objects,and were divided into observation group and control group(40 cases in each group)according to random number table.The control group was given febuxostat tablets orally,and the observation group was additionally given Jiangniaosuan Prescription.The therapeutic efficacy,adverse reactions,TCM syndrome scorse,blood uric acid level and serum inflammatory factors of phlegm-turbidity obstruction syndrome before and after treatment were compared in two groups.Results The effective rate of the observation group(95.00%,38/40)was higher compared with that of the control group(80.00%,32/40)(P<0.05).After treatment,the joint swelling,local sore and pain,dizziness,floating face and foot swelling,chest and epigastric swelling and other TCM syndromes were reduced in both groups compared with those before treatment,and the scores of TCM syndromes in the observation group were lower compared with those in the control group(P<0.05).The levels of blood uric acid,serum IL-6,IL-1βand tumor necrosis factor-α(TNF-α)in both groups were decreased after treatment,and the indexes in the observation group were lower compared with those in the control group(P<0.05).The rate of side reactions had no statistical significance between observation group(15.00%,6/40)and control group(10.00%,4/40)(P>0.05).Conclusion The adjuvant treatment of Jiangniaosuan Prescription for gout accompanied by hyperuricemia is effective,which can reduce the TCM syndrome scores of patients,reduce the levels of blood uric acid and serum IL-6 and IL-1βand improve the body inflammatory response.It is worthy of clinical promotion and application.

关 键 词：降尿酸方 痛风 高尿酸血症 血清白细胞介素-6 白细胞介素-1Β 

分 类 号：R256.5[医药卫生—中医内科学]