中风气血汤治疗中风病-中经络效果观察  

Clinical Observation of Zhongfeng Qixue Decoction(中风气血汤)Treating Patients with Apoplexy of Attacking Meridians Type

作　　者：黄永军 安红伟 周哲屹 HUANG Yongjun;AN Hongwei;ZHOU Zheyi(Department of Encephalopathy,Liuzhou Hospital of Traditional Chinese Medicine,Liuzhou 545001,Guangxi,China)

机构地区：[1]柳州市中医医院,广西柳州545001

出　　处：《辽宁中医杂志》2024年第5期67-70,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81760902);广西壮族自治区中医药管理局自筹经费科研课题项目(GXZYZ20210302);广西科技计划项目(桂科AB16380233)

摘　　要：目的 分析中风病-中经络(气虚血瘀证)患者应用中风气血汤治疗效果。方法 选择2019年1月—2022年1月医院收治的328例中风病-中经络患者加以研究,随机数字表法分观察组与对照组,各164例,对照组予以常规西药治疗,观察组在对照组的基础之上联用中风气血汤治疗;分析两组总有疗效,比较两组治疗前与治疗1个月后中医证候积分、 Barthel指数量表(Barthel index scale, MBI)、美国国立卫生院神经功能缺损量表(national institutes of health neurological impairment scale, NIHSS)评分、炎性因子[白细胞介素-6(interleukin-6,IL-6)、高敏C反应蛋白(high sensitivity C-reactive protein, hs-CRP)及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]、凝血相关指标[血小板聚集率(PAR)、活化部分凝血酶时间(activated partial thrombiu time, APTT)、D-二聚体(D-dimer, D-D)]的变化。结果 观察组总有效率明显高于对照组(P<0.05)[96.95%(159/164)vs 90.24%(148/164)]。治疗后,观察组中医证候总积分及NIHSS评分均明显少于对照组(P<0.05);观察组MBI评分明显高于对照组(P<0.05)。治疗后,观察组IL-6、hs-CRP及TNF-α水平皆明显低于对照组(P<0.05)。治疗后,观察组PAR、D-D水平皆明显低于对照组(P<0.05)。观察组APTT水平皆高于对照组(P<0.05)。结论 中风气血汤治疗中风病-中经络(气虚血瘀证)疗效显著,改善中医证候积分、MBI、NIHSS评分,降低炎性因子水平,有效调节凝血相关指标。Objective To analyze the effect of Zhongfeng Qixue Decoction(中风气血汤)on patients with apoplexy of attacking meridians type(Qi deficiency and blood stasis syndrome).Methods A total of 328 cases of apoplexy of attacking merdians type(Qi deficiency and blood stasis syndrome)admitted to the hospital from January 2019 to January 2022 were selected for the study.According to the random number table method,the patients were divided into observation group and control group,164 cases in each group.The control group was treated with conventional Western medicine,and the observation group was treated with Zhongfeng Qixue Decoction on the basis of the control group.The total effective rates of the two groups were analyzed.The TCM syndrome scores of the two groups before treatment and one month after treatment were compared.Barthel Index scale(MBI),National Institutes of Health Neurological Impairment Scale(NIHSS)score,inflammatory factors[interleukin-6(IL-6),high sensitivity C-reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α)],clotting related indicators[platelet aggregation rate(PAR),activated partial thrombin time(APTT),D-dimer(D-D)]of two groups were compared.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05)[96.95%(159/164)vs 90.24%(148/164)].After treatment,the total scores of TCM syndrome and NIHSS score in the observation group were significantly lower than those in the control group(P<0.05).The MBI score of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the levels of IL-6,hs-CRP and TNF-αin the observation group were significantly lower than those in the control group(P<0.05).After treatment,the levels of PAR and D-D in the observation group were significantly lower than those in the control group(P<0.05).The levels of APTT in the observation group were higher than those in the control group(P<0.05).Conclusion Zhongfeng Qiqi Decoction is effective in the treatment of apople

关 键 词：中风病-中经络 气虚血瘀证 中风气血汤 Barthel指数量表 NIHSS评分 炎性因子 

分 类 号：R255.2[医药卫生—中医内科学]