玄乌止痛膏穴位贴敷联合加味芍药甘草汤对癌性疼痛患者的疗效  

Effect of Acupoint Application with Xuanwu Zhitong Ointment(玄乌止痛膏)Combined with Modified Shaoyao Gancao Decoction(加味芍药甘草汤)on Patients with Cancer Pain

作　　者：李鑫 解晓芳 张光 刘泽生 LI Xin;XIE Xiaofang;ZHANG Guang;LIU Zesheng(Department of Oncology,Zhangjiakou Hospital of Traditional Chinese Medicine,Zhangjiakou 075000,Hebei,China)

机构地区：[1]张家口市中医院肿瘤科,河北张家口075000

出　　处：《辽宁中医杂志》2024年第5期164-167,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：张家口市重点研发计划项目(2121051D)

摘　　要：目的 探讨玄乌止痛膏穴位贴敷联合加味芍药甘草汤对癌性疼痛患者的临床效果。方法 择取2021年10月—2022年6月该院收治的癌性疼痛患者96例,将其划分为观察组、对照组,每组48例,依据随机、双盲、安慰剂平行对照的临床研究方法。给予对照组三阶梯止痛药物治疗,给予观察组玄乌止痛膏穴位贴敷联合加味芍药甘草汤口服,必要时可加用三阶梯止痛药物,均给予两组1个月的治疗时间。将观察组、对照组患者的临床疗效、数字分级法(numerical rating scale, NRS)评分、止痛起效和持续时间、治疗前与治疗后的疼痛介质相关指标、生活质量及治疗期间的不良反应进行统一的对比与分析。结果 治疗后较对照组(64.58%,31/48)比,观察组的镇痛总有效率(83.33%,40/48)处于较高水平;经与对照组相比,观察组患者的止痛起效时间更短,持续时间更长;治疗后,两组患者NRS评分、5-羟色胺(5-hydroxytryptamine, 5-HT)、前列腺素E2(prostaglandin E_(2),PGE_(2))、内皮素(endothelin, ET)-1、P物质(SP)与治疗前相比较,均呈现降低趋势,其中较对照组比,观察组均处于较低水平;治疗后,两组患者生活质量综合评定问卷(GQOL-74)各项评分与治疗前相比较,均呈现明显升高趋势,其中较对照组比,观察组处于较高水平,P<0.05,提示其数据经计算有显著性差异;经比较,观察组与对照组患者治疗期间的不良反应总发生率,P>0.05,提示其数据经计算差异无统计学意义。结论 癌性疼痛患者应用玄乌止痛膏穴位贴敷联合加味芍药甘草汤治疗效果较为显著,可减轻患者疼痛,提升整体生活质量,不良反应较少,安全性高。Objective To explore the clinical effect of acupoint application with Xuanwu Zhitong Ointment(玄乌止痛膏)combined with Modified Shaoyao Gancao Decoction(加味芍药甘草汤)on patients with cancer pain.Methods The study subjects were the patients with cancer pain admitted to the hospital.A total of 96 cases were selected from October 2021 to June 2022 and were divided into the observation group and the control group,with 48 cases in each group,according to the randomized,double-blind,placebo parallel control clinical research method.The control group was given three-step analgesic drug treatment.The observation group was given acupoint application with Xuanwu Zhitong Ointment combined with Modified Shaoyao Gancao Decoction.The three-step analgesic drugs could be added when necessary.Both groups were given 1 month of treatment time.The clinical efficacy,numerical rating scale(NRS)score,analgesic onset and duration,pain mediators,quality of life before and after treatment and adverse reactions of the two groups during treatment were compared and analyzed.Results After treatment,the total effective rate of analgesia in the observation group(83.33%,40/48)was higher than that in the control group(64.58%,31/48).Compared with those of the control group,the analgesic onset time was shorter and the duration was longer in the observation group.After treatment,NRS scores,the levels of 5-hydroxytryptamine(5-HT),prostaglandin E_(2)(PGE_(2)),endothelin(ET)-1 and substance P(SP)in both groups showed a decreasing trend compared with those before treatment,and those of the observation group were at a lower level than those of the control group.After treatment,the scores of Generic Quality of Life Inventory 74(GQOL-74)in both groups showed a significantly higher trend than those before treatment.Compared with the scores of the control group,the scores of the observation group were at a higher level(P<0.05),indicating a significant difference in data after calculation.The total incidence of adverse reactions between the obse

关 键 词：癌性疼痛 玄乌止痛膏 穴位贴敷 芍药甘草汤 疼痛 生活质量 

分 类 号：R245.9[医药卫生—针灸推拿学]