不同环境下烯丙孕素片崩解与溶出性能的实验研究  

Experimental study on disintegration and dissolution properties of alprogesterone tablets under different environments

作　　者：张晶[1] 刘凯卫 ZHANG Jing;LIU Kai-Wei(Fujian Agricultural Products Quality and Safety Inspection and Testing Center,Fuzhou 350003,China;Famo(Fujian)Biotechnology Co.,Ltd.,Zhangzhou 363100,China)

机构地区：[1]福建省农产品质量安全检验检测中心,福州350003 [2]法茉(福建)生物科技有限公司,漳州363100

出　　处：《实验室检测》2024年第9期27-30,共4页Laboratory Testing

摘　　要：目的以烯丙孕素为对象,探讨其在不同环境条件下作为饲料添加剂的崩解与溶出性能,开发适合猪场饲养需求的片剂。方法通过3因素3水平正交试验筛选处方,并对片剂的崩解时限、溶出度、外观质量等性能进行检测。结果优化后的烯丙孕素实现了7~15 min的崩解时限,优于常规片剂的2~5 min。结论优化后的烯丙孕素溶出度和含量符合标准,便于母猪摄食,能够满足猪场饲需求。Objective To investigate the disintegration and dissolution properties of alprogesterone as a feed additive under different environmental conditions,and to develop a suitable tablet for pig farm feeding.Methods The prescription was screened by 3-factor and 3-level orthogonal test,and the disintegration time,dissolution and appearance quality of the tablets were tested.Results The disintegration time of the optimized allyl gestrel was 7~15 min,which was better than 2~5 min of conventional tablets.Conclusion The optimized dissolution and content of allyl gestrel meet the standard,which is convenient for sows to consume and can meet the feeding needs of pig farms.

关 键 词：烯丙孕素 溶出性能 崩解 水平正交试验 

分 类 号：S816.7[农业科学—饲料科学]