支气管镜肺泡灌洗辅助治疗对重症肺炎患儿血清 YKL-40、sIL-2R、Copeptin水平的影响  

Effect of Bronchoscopic Alveolar Lavage on Serum YKL-40、sIL-2R And Copeptin Levels in Children with Severe Pneumonia And Analysis of Prognostic Risk Factors

作　　者：季鹏 张云[2] Ji Peng;Zhang Yun(Department of Pediatrics,The Second People's Hospital of Changzhou City,Changzhou Jiangsu 213000,China;Department of Pediatrics,Changzhou First People's Hospital,Changzhou Jiangsu 213000,China)

机构地区：[1]常州市第二人民医院儿科,江苏常州213000 [2]常州市第一人民医院儿科,江苏常州213000

出　　处：《生命科学仪器》2024年第4期73-75,共3页Life Science Instruments

摘　　要：目的研究分析支气管镜肺泡灌洗(BAL)辅助治疗对重症肺炎(SP)患儿血清甲壳质酶蛋白40(YKL-40)、可溶性白细胞介素-2受体(sIL-2R)、和肽素(Copeptin)水平的影响。方法选取医院2021年12月至2023年12月期间收治的81例SP患儿,随机分为灌洗组(n=40)与常规组(n=41)。常规组开展常规治疗,灌洗组在常规治疗基础上辅以BAL治疗。对比两组临床疗效、血清YKL-40、sIL-2R、Copeptin水平。结果灌洗组治疗总有效率高于常规组,P<0.05。治疗后,灌洗组血清YKL-40、sIL-2R、Copeptin水平均低于常规组,P<0.05。结论BAL辅助治疗SP患儿的疗效较佳,且能负向调控血清YKL-40、sIL-2R、Copeptin水平。Objective:To study and analyze the effects of bronchoalveolar lavage(BAL)on serum levels of chitinase protein 40(YKL-40)、soluble interleukin-2 receptor(sIL-2R)and peptide(Copeptin)in children with severe pneumonia(SP).Methods:Eighty-one children with SP from December 2021 to December 2023 were randomly divided into lavage group(n=40)and routine group(n=41).Routine treatment was carried out in the routine group,and BAL treatment was supplemented in the lavage group on the basis of routine treatment.The clinical efficacy、serum levels of YKL-40、sIL-2R and Copeptin were compared between the two groups.Results:The total effective rate of lavage group was higher than that of routine group,P<0.05.After treatment,the serum levels of YKL-40、sIL-2R and Copeptin in lavage group were lower than those in routine group,P<0.05.Conclusion:BAL is effective in adjuvant treatment of children with SP,and can negatively regulate the serum levels of YKL-40、sIL-2R and Copeptin.

关 键 词：重症肺炎 支气管镜肺泡灌洗 甲壳质酶蛋白40 可溶性白细胞介素-2受体 和肽素 

分 类 号：R563.1[医药卫生—呼吸系统]