鼻咽癌放化疗患者营养状态及其与癌因性疲乏的相关性研究  

The Relationship between Nutritional Status And Cancer-induced Fatigue in Patients with Nasopharyngeal Carcinoma Treated with Radiotherapy And Chemotherapy

作　　者：蔡妮娜 罗洁 Cai Nina;Luo Jie(Department of Oncology,tongji hospital Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei 430000)

机构地区：[1]华中科技大学同济医学院附属同济医院肿瘤科,湖北武汉430000

出　　处：《生命科学仪器》2024年第4期65-67,共3页Life Science Instruments

摘　　要：目的观察分析鼻咽癌放疗患者营养状态及其与癌因性疲乏的相关性。方法选取2022年3月至2023年3月华中科技大学同济医学院附属同济医院收治的88例鼻咽癌患者,在放疗期间前1 d(T1)及放疗第15次(T2)、放疗第30次(T3)、放疗结束后(T4),采用营养风险评估表(NRS2002)及癌因性疲乏量表(CRF)评估其营养状态、癌因性疲乏情况,检测营养相关生化指标。结果鼻咽癌放化疗患者在治疗过程中不同时间点的血清白蛋白、前白蛋白、淋巴细胞、血红蛋白对比,P<0.05,且较治疗前均降低;鼻咽癌放化疗患者治疗后营养不良率为28.4%、52.27%、73.86%、98.86%,呈上升趋势,P<0.05;治疗后,鼻咽癌放化疗患者各时间点CRF量表评分呈上升趋势,P<0.05;鼻咽癌放化疗患者各时间点NRS评分与CRF维度评分及总分均呈正相关性,P<0.05。结论鼻咽癌患者放化疗期间营养不良风险比例偏高,变化趋势呈上升状,其营养状态与癌因性疲乏相关,需积极给予营养支持,以降低癌因性疲乏程度。Objective:To observe and analyze the nutritional status of nasopharyngeal carcinoma patients undergoing radiotherapy and its correlation with cancer-related fatigue.Methods:From March 2022 to March 2023,88 patients with nasopharyngeal carcinoma admitted to tongji hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology were selected.Their nutritional status and cancer-related fatigue scale(CRF)were used to evaluate their nutritional status 1 day before radiotherapy(T1)、the 15th radiotherapy(T2)、the 30th radiotherapy(T3)and after radiotherapy(T4).Results:The serum albumin、prealbumin、lymphocyte and hemoglobin of patients with nasopharyngeal carcinoma during radiotherapy and chemotherapy were compared at different time points,P<0.05,and they were all lower than before treatment.The malnutrition rates of nasopharyngeal carcinoma patients after radiotherapy and chemotherapy were 28.4%、52.27%、73.86%and 98.86%,showing an upward trend,P<0.05;After treatment,the CRF scores of nasopharyngeal carcinoma patients with radiotherapy and chemotherapy showed an upward trend at each time point,P<0.05.NRS score was positively correlated with CRF dimension score and total score at each time point in patients with nasopharyngeal carcinoma undergoing radiotherapy and chemotherapy,P<0.05.Conclusion:The risk ratio of malnutrition in patients with nasopharyngeal carcinoma during radiotherapy and chemotherapy is high,and the change trend is on the rise.Their nutritional status is related to cancer-related fatigue,so active nutritional support is needed to reduce the degree of cancer-related fatigue.

关 键 词：鼻咽癌 癌因性疲乏 营养状态 化疗 

分 类 号：R473.73[医药卫生—护理学]