达格列净对急诊PCI治疗急性心梗患者心脏超声指标的影响  

Effect of Dagliflozin on Cardiac Ultrasound Index in Patients with Acute Myocardial Infarction

作　　者：陆稼 席银娟 Lu Jia;Xi Yinjuan(944th Hospital of Joint Logistic Support Force,Jiuquan 735000;Jiuquan Hospital of Shanghai First People's Hospital(Jiuquan People's Hospital),Jiuquan Gansu 735000,China)

机构地区：[1]联勤保障部队第九四四医院,甘肃酒泉735000 [2]上海市第一人民医院酒泉医院(酒泉市人民医院),甘肃酒泉735000

出　　处：《生命科学仪器》2024年第4期20-22,共3页Life Science Instruments

基　　金：酒泉市科技计划项目(沙库巴曲缬沙坦联合达格列净治疗扩张型心肌病心衰患者短中期疗效观察)(项目编号:2022MB1018)

摘　　要：目的探讨分析达格列净对急性心肌梗死(AMI)急诊经皮冠状动脉介入术(PCI)治疗患者心脏超声指标的影响。方法选择在医院行急诊PCI治疗的95例AMI患者作为研究对象,就诊时间2022年1月-2023年10月,通过计算机随机数字软件生成数字1-95,双数者为对照组(n=47),行常规对症治疗;单数者为观察组(n=48),术后加用达格列净治疗。对比重大心血管事件、不良反应发生情况及心脏超声指标。结果治疗3个月后,两组室舒张末期内径、左室舒张末期容积降低,左室射血分数升高,且观察组更低、更高P<0.05。观察组重大心血管事件发生率较对照组更低,P<0.05。两组不良反应发生率对比,P>0.05。结论在AMI急诊PCI治疗患者中应用达格列净可进一步改善其心脏超声指标,减少重大心血管事件发生,且不会增加其用药风险。Objective:To explore and analyze the effect of dapagliflozin on cardiac ultrasound indicators in patients undergoing emergency percutaneous coronary intervention(PCI)for acute myocardial infarction(AMI).Method:95 patients with acute myocardial infarction(AMI)who underwent emergency PCI treatment in the hospital were selected as the research subjects.The treatment period was from January 2022 to October 2023.The numbers 1-95 were generated using computer random number software,and the control group(n=47)received routine symptomatic treatment;The observation group(n=48)consisted of individuals with odd numbers,who received additional treatment with dapagliflozin after surgery.Compare the occurrence of major cardiovascular events,adverse reactions,and cardiac ultrasound indicators.After:3 months of treatment,both groups showed a decrease in end diastolic diameter and left ventricular end diastolic volume,as well as an increase in left ventricular ejection fraction,with lower and higher values observed in the observation group(P<0.05).The incidence of major cardiovascular events in the observation group was lower than that in the control group,P<0.05.The incidence of adverse reactions between the two groups was compared,P>0.05.Conclusion:The application of dapagliflozin in AMI emergency PCI treatment patients can further improve their cardiac ultrasound indicators,reduce the occurrence of major cardiovascular events,and does not increase their medication risk.

关 键 词：达格列净 急诊 经皮冠状动脉介入术 急性心梗 心脏超声指标 

分 类 号：R541.4[医药卫生—心血管疾病]