双酚A暴露对雌性性激素的影响及其作用机制的研究进展  

Effects and mechanism of bisphenol A exposure on female sex steroid hormones:a review of recent studies

作　　者：关添月 郝加虎[1] GUAN Tian-yue;HAO Jia-hu(Department of Woman and Child's Care and Adolescence Health,School of Public Health,Anhui Medical University(AHMU),Hefei,Anhui 230032,China;不详)

机构地区：[1]安徽医科大学公共卫生学院儿少卫生与妇幼保健学系,安徽合肥230032

出　　处：《环境与健康杂志》2025年第1期80-85,共6页Journal of Environment and Health

基　　金：国家自然科学基金(81872635,81573164)

摘　　要：双酚A(bisphenol A,BPA)作为一种环境内分泌干扰物,可以通过不同的暴露途径进入人体,并对人体健康产生不良影响,如生殖毒性、神经发育毒性甚至激素相关肿瘤等。BPA结构类似于雌激素,生殖毒性较强,可能会抑制雌性体内的雌激素与孕激素水平,且上调雄激素水平。同时,BPA可能通过影响胆固醇合成稳态、改变性类固醇激素相关通路以及损害卵泡功能的途径作用于机体,从而影响性激素水平。笔者主要从BPA作用于雌性的性激素出发,对机体的雌激素、孕激素和雄激素的下调作用,以及通过影响胆固醇合成稳态等机制进行综述,有助于阐明双酚A通过影响性激素导致健康损害,为预防这些内分泌干扰物产生的健康危害提供更为全面的解决思路。Bisphenol A(BPA),an environmental endocrine disruptor,can enter the human body through different exposure routes and have adverse effects on human health,such as reproductive toxicity,neurodevelopmental toxicity and even hormone-related tumors.The structure of BPA is similar to estrogen and it is highly toxic to reproduction.It may inhibit the levels of estrogen and progesterone in females and up-regulate androgen levels.At the same time,BPA may act on the body by affecting the homeostasis of cholesterol synthesis,altering sex steroid hormone-related pathways and impairing follicular function,thereby affecting sex hormone levels.The present paper mainly started from the effect of BPA on female sex hormones and reviewed the down-regulation of estrogen,progesterone and androgen in the body,as well as the mechanism of affecting the homeostasis of cholesterol synthesis,and these are helpful to clarify that bisphenol A can cause health damage by affecting sex hormones,to provide a more comprehensive solution for preventing the health hazards caused by these endocrine disruptors.

关 键 词：双酚A 雌性 性类固醇激素 雌激素类 孕激素类 雄激素类 

分 类 号：R994.6[医药卫生—毒理学]