血清肌酐、胱抑素-C、尿素氮及尿β_(2)-微球蛋白检测在2型糖尿病早期肾损伤诊断中的价值  

The Value of Serum Creatinine、Cystatin-C、urea nitrogen and Urinary β_(2)-microglobulin Tests in Early Kidney Injury in Type 2 Diabetes Mellitus

作　　者：李娜 许陈裔 Li Na;Xu Chenyi(Haimen NO.5 People's Hospital Inspection Department,Haimen Jiangsu 226100,China;Nantong Haimen District Center for Disease Control and Prevention,Haimen Jiangsu 226100,China)

机构地区：[1]南通市海门区悦来镇中心卫生院检验科,江苏海门226100 [2]南通市海门区疾病预防控制中心检验科,江苏海门226100

出　　处：《生命科学仪器》2024年第5期21-23,共3页Life Science Instruments

摘　　要：目的 探究在2型糖尿病早期肾损伤诊断中联合应用血清肌酐、胱抑素-C、尿素氮及尿β_(2)-微球蛋白检测的临床价值。方法 选择2023年1月至2023年12月期间南通市海门区悦来镇中心卫生院收治的2型糖尿病早期肾损伤患者50例,作为研究组;同时抽取医院同期健康体检人员50名,作为对照组。两组均接受血清肌酐、胱抑素-C、尿素氮及尿β_(2)-微球蛋白检测,观察对比两组各指标水平,分析联合检测对2型糖尿病早期肾损伤的诊断效能。结果 研究组血清肌酐、胱抑素-C、尿素氮及尿β_(2)-微球蛋白水平分别较对照组高,P<0.05;联合指标检测诊断2型糖尿病早期肾损伤的灵敏度、准确度均较各指标单独检测更高,P<0.05;各指标间特异度比较,P>0.05。结论 2型糖尿病早期肾损伤患者血清肌酐、胱抑素-C、尿素氮及尿β_(2)-微球蛋白水平均呈明显升高状态;通过联合指标检测,可有效提升2型糖尿病早期肾损伤的诊断效能。Objective:To explore the clinical value of combined detection of serum creatinine、cystatin-C、urea nitrogen and urineβ_(2)-microglobulin in the diagnosis of early renal injury in type 2 diabetes mellitus.Methods:50 patients with early renal injury of type 2 diabetes mellitus admitted to Yuelai Town Central Health Center in Haimen District of Nantong City from January 2023 to December 2023 were selected as the research group.At the same time,50 healthy physical examination personnel were selected as the control group.Serum creatinine、cystatin-C、urea nitrogen and urineβ_(2)-microglobulin were detected in both groups,and the levels of each index in the two groups were observed and compared,and the diagnostic efficacy of combined detection for early renal injury in type 2 diabetes mellitus was analyzed.Results:The levels of serum creatinine、cystatin-C、urea nitrogen and urineβ_(2)-microglobulin in the study group were higher than those in the control group,respectively,P<0.05.The sensitivity and accuracy of combined indexes in the diagnosis of early renal injury in type 2 diabetes mellitus were higher than those of individual indexes,P<0.05.The specificity of each index was compared,P>0.05.Conclusion:The levels of serum creatinine、cystatin-C、urea nitrogen and urineβ_(2)-microglobulin in patients with early renal injury in type 2 diabetes mellitus are obviously increased.Combined index detection can effectively improve the diagnostic efficiency of early renal injury in type 2 diabetes.

关 键 词：2型糖尿病 早期肾损伤 血清肌酐 胱抑素C 尿素氮 尿β_(2)-微球蛋白 

分 类 号：R587.1[医药卫生—内分泌]