麻城地区发热伴血小板减少综合征患者的临床症状及新型布尼亚病毒量动态变化分析  

Analysis of the Clinical Symptoms And the Dynamic Changes of the Amount of Novel Bunia Virus in Severe Fever with Thrombocytopenia Syndrome Patients in Macheng

作　　者：周意红 陶奔 张志刚 雷远锋 陈敬锋 Zhou Yihong;Tao Ben;Zhang Zhigang;Lei Yuanfeng;Chen Jingfeng(Macheng People's Hospital,Macheng Hubei 438300,China)

机构地区：[1]麻城市人民医院,湖北麻城438300

出　　处：《生命科学仪器》2024年第5期155-157,共3页Life Science Instruments

基　　金：湖北科技学院医学部教学基地教研科研项目,项目编号:2023YJDKY09

摘　　要：目的 探讨分析麻城地区发热伴血小板减少综合征(SFTS)患者的临床特点及新型布朗尼病毒(SFTSV)量与临床症状和预后的关系。方法 回顾性分析2020年4月至2023年10月麻城市人民医院收治的120例SFTS患者的临床资料,采用RT-qPCR检测其体内的SFTSV量。根据SFTSV量中位数将患者分为高病毒量组(≥5.0 log10 copies/ml)和低病毒量组(<5.0 log10 copies/ml),比较两组患者的SFTSV量动态变化及预后,并采用多因素Logistic回归分析影响SFTS患者预后的因素。结果 120例SFTS患者平均年龄(58.3±13.2)岁,男女比例接近,实验室检查显示其白细胞、血小板计数等多项指标异常,SFTSV量中位数为5.1 log10 copies/ml。高病毒量组死亡率(28.6%)显著高于低病毒量组(8.3%),P<0.05。Logistic回归分析显示,高病毒量(OR=4.32,P<0.05)、血小板减少(OR=3.76,P<0.05)、肝功能损害(OR=5.21,P<0.05)是SFTS患者死亡的独立危险因素。结论 SFTS患者的实验室检查多见异常,其体内的SFTSV量与临床症状及预后密切相关。高病毒量、血小板减少和肝功能损害是影响SFTS患者预后的重要因素。Objective:To explore and analyze the clinical characteristics of patients with fever and thrombocytopenia syndrome(SFTS)in Macheng area and the relationship between the amount of novel Brownie virus(SFTSV)and clinical symptoms and prognosis.Methods:The clinical data of 120 patients with SFTS admitted to Macheng People's Hospital from April 2020 to October 2023 were analyzed retrospectively,and the amount of SFTSV in their bodies was detected by RT-QCPR.According to the median amount of SFTSV,patients were divided into high virus amount group(≥5.0 log10 copies/ml)and low virus amount group(<5.0 log 10 copies/ml).The dynamic changes and prognosis of SFTSV in the two groups were compared,and the factors affecting the prognosis of SFTS patients were analyzed by multivariate Logistic regression.Results:120 patients with SFTS,with an average age of(58.3±13.2)years,and the ratio of male to female was similar.Laboratory tests showed that their white blood cells and platelet counts were abnormal,and the median amount of SFTSV was 5.1 log10 copies/ml.The mortality rate of high viral load group(28.6%)was significantly higher than that of low viral load group(8.3%),P<0.05.Logistic regression analysis showed that high viral load(OR=4.32,P<0.05),thrombocytopenia(OR=3.76,P<0.05)and liver function damage(OR=5.21,P<0.05)were independent risk factors for the death of SFTS patients.Conclusion:Laboratory tests of patients with SFTS are often abnormal,and the amount of SFTSV in their bodies is closely related to clinical symptoms and prognosis.High viral load,thrombocytopenia and liver damage are important factors affecting the prognosis of patients with SFTS.

关 键 词：发热伴血小板减少综合征 新型布尼亚病毒 病毒量 

分 类 号：R183.5[医药卫生—流行病学]