评估40例急性布鲁氏菌病合并血清钙水平降低患者骨盐代谢水平  

Evaluation of bone salt metabolism levels in 40 patients with acute brucellosis complicated by decreased serum calcium levels

作　　者：侯毅[1] 韩丽红[2] 马淑一[2] Hou Yi;Han Lihong;Ma Shuyi(Physical Examination Department of Baotou Central Hospital,Baotou 014040,China;School of Medical Technology and Anesthesia,Baotou Medical University,Baotou 014060,China)

机构地区：[1]包头市中心医院体检科,包头014040 [2]包头医学院医学技术与麻醉学院,包头014060

出　　处：《中华地方病学杂志》2024年第12期1001-1003,共3页Chinese Journal of Endemiology

基　　金：内蒙古自治区卫生健康委医疗卫生科技计划项目(202201374、202202302、202201390);包头市卫生健康委科技计划项目(wsjkkj072);包头医学院布鲁氏菌病研究(培育)团队(bycxtd-14)

摘　　要：目的评估急性布鲁氏菌病(简称布病)合并血清钙水平降低患者骨盐代谢水平。方法采用前瞻性设计,以2021年1-12月包头市东河区疾病预防控制中心确诊的40名急性布病合并血清钙水平降低患者作为低钙急性布病组,以当地30名健康人作为对照组。采用全自动化学发光免疫分析仪检测调节激素指标血清甲状旁腺激素(PTH)、25-羟基维生素D_(3)[25-(OH)VD_(3)]水平和骨矿物质指标血清钙、磷、镁水平,比较两组间上述指标表达差异。结果与对照组比较,低钙急性布病组血清PTH、25-(OH)VD_(3)水平均较低[(23.15±9.78)比(54.34±15.31)pg/ml,(16.68±5.48)比(46.23±16.79)ng/L,t=4.96、15.03,均P<0.001];血清钙水平较低[(0.94±0.14)比(1.23±0.23)mmol/L,t=6.11,P<0.001],血清磷、镁水平均较高[(2.98±0.68)比(1.90±0.25)、(1.13±0.21)比(0.90±0.48)mmol/L,t=7.51、7.70,均P<0.001]。结论急性布病合并血清钙水平降低患者可出现骨盐代谢水平异常。Objective To evaluate the bone salt metabolism levels of patients with acute brucellosis complicated by decreased serum calcium levels.Methods Forty patients with acute brucellosis complicated by decreased serum calcium levels diagnosed by the Disease Prevention and Control Center of Donghe District,Baotou City from January to December 2021 were selected as the low calcium acute brucellosis group,and 30 local healthy people were selected as the control group.The fully automatic chemiluminescence immunoassay analyzer was used to determine the levels of regulatory hormone indicators such as serum parathyroid hormone(PTH),25-hydroxyvitamin D_(3)[25-(OH)VD_(3)],and bone mineral indicators such as serum calcium,phosphorus,and magnesium.The expression difference of the above indexes between the two groups was compared.Results Compared with the control group,the serum PTH and 25-(OH)VD_(3)levels in the low calcium acute brucellosis group were lower[(23.15±9.78)vs(54.34±15.31)pg/ml,(16.68±5.48)vs(46.23±16.79)ng/L,t=4.96,15.03,P<0.001];the serum calcium level was lower[(0.94±0.14)vs(1.23±0.23)mmol/L,t=6.11,P<0.001],while the serum phosphorus and magnesium levels were higher[(2.98±0.68)vs(1.90±0.25)mmol/L,(1.13±0.21)vs(0.90±0.48)mmol/L,t=7.51,7.70,P<0.001].Conclusion Patients with acute brucellosis complicated by decreased serum calcium levels may experience abnormal bone salt metabolism hormones.

关 键 词：布鲁氏菌病 甲状旁腺激素 25-羟基维生素D_(3) 钙 

分 类 号：R516.7[医药卫生—内科学]