宫糜散对宫颈高危型人乳头状瘤病毒感染患者LEEP术后疗效观察  

The Efficacy of Gongmi Powder in Patients with High-risk Human Papillomavirus Cervical Infection after LEEP Surgery

作　　者：黄健妹[1] 陈敏[1] HUANG Jianmei;CHEN Min(Department of Gynecology,Quanzhou Hospital of Traditional Chinese Medicine,Fujian Quanzhou 362005)

机构地区：[1]泉州市中医院妇科,福建泉州362005

出　　处：《深圳中西医结合杂志》2024年第21期1-5,共5页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：泉州市科技计划项目(2019N062S);福建省第四批名老中医药学术经验继承项目(闽卫中医函[2021]339号)。

摘　　要：目的:探究宫糜散治疗宫颈高度鳞状上皮病变(HSIL)伴高危型人乳头状瘤病毒(HR-HPV)感染患者子宫颈环形电切除术(LEEP)后的临床疗效。方法:选取2019年11月至2022年12月泉州市中医院妇科收治的符合条件的HSIL伴HR-HPV感染LEEP后患者共90例,按照随机数字表法分为对照组、干扰素组和宫糜散组,每组30例。对照组患者LEEP后不予局部治疗;干扰素组患者LEEP后使用重组人干扰素a2b阴道泡腾胶囊纳阴治疗;宫糜散组患者LEEP后用宫糜散阴道局部用药治疗,疗程均为3个月。比较治疗前后各组患者的临床疗效、阴道微环境指标[白细胞计数(WBC)、氢离子浓度指数(pH)、唾液酸苷酶阳性率、过氧化氢阳性率、白细胞酯酶阳性率]以及疗程结束后3个月HR-HPV复查情况。结果:治疗3个月后复查,宫糜散组、干扰素组患者HR-HPV治疗总有效率均高于对照组,差异具有统计学意义(P<0.05);宫糜散组、干扰素组患者治疗总有效率比较,差异无统计学意义(P>0.05)。宫糜散组患者WBC、pH、唾液酸苷酶阳性率、过氧化氢阳性率、白细胞酯酶阳性率均低于干扰素组、对照组,差异具有统计学意义(P<0.05)。疗程结束后3个月复查,宫糜散组患者HR-HPV治疗总有效率均高于干扰素组、对照组,差异具有统计学意义(P<0.05);对照组、干扰素组两组患者的治疗总有效率比较,差异无统计学意义(P>0.05)。结论:HSIL伴HR-HPV感染LEEP术后患者辅以宫糜散能提高HR-HPV的清除率,改善阴道的微环境,对于预防宫颈病变的加重、复发具有积极的意义。Objective To explore the clinical efficacy of Gongmi Powder in the treatment of cervical high-grade squamous intraepithelial lesions(HSIL)with high-risk human papillomavirus(HR-HPV)infection after loop electrosurgical excision procedure(LEEP).Methods A total of 90 eligible patients with HSIL and HR-HPV infection after LEEP admitted to the Department of Gynecology of Quanzhou Hospital of Traditional Chinese Medicine from November 2019 to December 2022 were divided into a control group,an interferon group,and Gongmi Powder group according to a random number table,with 30 cases in each group.Patients in the control group received no local treatment after LEEP;patients in the interferon group were treated with recombinant human interferon α2b vaginal effervescent capsules after LEEP;patients in the Gongmi Powder group were treated with Gongmi Powder for vaginal local medication after LEEP,with a treatment course of 3 months for all groups.The clinical efficacy,vaginal microenvironment indicators[white blood cell count(WBC),hydrogen ion concentration index(pH),sialidase positive rate,hydrogen peroxide positive rate,leukocyte esterase positive rate]before and after treatment for 3 months,and the review situation of HRHPV at 3 months after the completion of the treatment were compared among the groups.Results At the 3-month follow-up,the total effective rate of treatment in the Gongmi San group and the interferon group was higher than that in the control group,with statistically significant differences(P<0.05);there was no statistically significant difference in the total effective rate of treatment between the Gongmi San group and the interferon group(P>0.05).The WBC,pH,sialidase positive rate,hydrogen peroxide positive rate,and leukocyte esterase positive rate in the Gongmi San group were lower than those in the interferon group and the control group,with statistically significant differences(P<0.05).And 3 months after the completion of the treatment,the total effective rate of treatment in the Gongmi San group was h

关 键 词：宫颈高度鳞状上皮内病变 高危型人乳头状瘤病毒 宫糜散 子宫颈环形电切除术 

分 类 号：R711.74[医药卫生—妇产科学]