90天-6°卧床后重力再适应过程中大脑局部功能活动重塑研究  

Study on neuroplasticity of local functional activity of the brain during gravity re-adaptation after 90 days-6 degree head-down bed rest

作　　者：刘雅文 任鹏玲 李铠 蔡林坤 张婷婷[1,4] 吕柯 乔鹏岗[1] 吕晗 罗德红[5] 曲丽娜[3] 李莹辉[3] 王振常[1,2] Liu Yawen;Ren Pengling;Li Kai;Cai Linkun;Zhang Tingting;Lyu Ke;Qiao Penggang;Lyu Han;Luo Dehong;Qu Lina;Li Yinghui;Wang Zhenchang(Department of Radiology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Precision and Intelligence Medical Imaging Lab,Beijing Clinical Research Institute,Beijing 100050,China;China Astronaut Research and Training Center,Beijing 100094,China;School of Biological Science and Medical Engineering,Beihang University,Beijing 100191,China;Department of Radiology,Cancer Hospital Chinese Academy of Medical Sciences,Shenzhen Center,Shenzhen 518116,China)

机构地区：[1]首都医科大学附属北京友谊医院放射科,北京100050 [2]北京市临床医学研究所精准与智慧影像实验室,北京100050 [3]中国航天员科研训练中心,北京100094 [4]北京航空航天大学生物与医学工程学院,北京100191 [5]中国医学科学院肿瘤医院深圳医院放射科,深圳518116

出　　处：《航天医学与医学工程》2024年第5期289-294,共6页Space Medicine & Medical Engineering

基　　金：载人航天工程空间站航天医学实验项目(No.HYZHXM01012);载人航天工程空间站医学实验项目(No.HYZHXMH01005);北京学者(京人社专家发[2015]160号);北京市医院管理中心创新梦工场经费资助(编号:202302);中国载人航天预先研究项目资助(地星二号―No.0040)。

摘　　要：目的比较并分析90 d、-6°卧床实验后,不同恢复时间下大脑局部功能活动变化,明确重力再适应过程中脑功能重塑机制,为脑功能恢复模型的构建与健康评估提供影像学依据与指导。方法36名男性健康志愿者在卧床前、90d卧床后恢复3d及后恢复26~28d时,分别进行静息态功能磁共振成像(rs-fMRI)扫描,计算局部一致性(ReHo)和低频振幅(ALFF)并进行不同时间点间的差异脑区分析。结果与卧床前相比,卧床后恢复3 d时,左侧顶下缘角回的ReHo降低,右侧后扣带回ALFF降低;左侧距状裂周围皮层及右侧舌回ReHo升高,左侧楔前叶、左侧旁中央小叶及右侧中央后回ALFF升高。后恢复26~28 d时,除上述脑区外,更多脑区表现出更显著的局部活动变化。结论90d长期卧床及后恢复可引起大脑的默认网络、感觉运动网络及视觉网络的神经功能活动发生改变,且较长时间的重力再适应恢复后会出现明显的适应性重塑现象。Objective To analyze and compare the changes in local functional activity of the brain under different recovery times after a 90-day,-6°head down bed rest(HDBR)experiment,clarify the mechanism of brain function remodeling during gravity adaptation,and provide imaging basis and guidance for the model construction and health assessment.Methods 36 healthy male volunteers underwent resting-state functional magnetic resonance imaging(rsfMRI)scans before HDBR(PRE),3 days after 90-day HDBR(R+3),and 26-28 days after 90-day HDBR(R+26-28),and calculated regional homogeneity(ReHo)and low-frequency amplitude(ALFF)and perform statistical analysis between different time points.Results Compared with PRE-status,ReHo value in the left inferior parietal gyrus and ALFF value in the right posterior cingulate gyrus decreased significantly in R+3 status,while ReHo value in the left calcarine,right lingual gyrus and ALFF value in the precuneus,left paracentral lobule,and right postcentral gyrus increased significantly.At R+26-28 status,more brain areas showed significant changes.Conclusion 90 days of longterm HDBR and subsequent recovery will lead to changes in the neural functional activities of the brain's default network,sensorimotor network and visual network,and obvious adaptive remodeling will occur after a longer period of gravity re-adaptation and recovery.

关 键 词：模拟失重 头低位卧床 重力再适应 大脑局部功能活动 神经重塑 

分 类 号：R47[医药卫生—护理学]