Platelet-derived extracellular vesicles for endometrial regeneration towards efficient live birth  

作　　者：Dongxiao Li Yanhong Yang Bo Tian Chenmeng Zhou Shuting Gu Wenju Chang Bingbing Wu Dantong Dong Fang Xu Ziyang Yu Ling Zhou Chao Wang Hong Zhang 

机构地区：[1]Department of Obstetrics and Gynecology,The Second Affiliated Hospital of Soochow University,Suzhou 215004,China [2]Institute of Functional Nano&Soft Materials(FUNSOM),Soochow University,Suzhou 215123,China [3]Department of Orthopedics,The Second Affiliated Hospital of Soochow University,Suzhou 215004,China

出　　处：《Nano Research》2025年第2期607-615,共9页纳米研究(英文版)

基　　金：This work was partly supported by the National Key R&D Program of China(No.2022YFB3808100);This work was supported by National Natural Science Foundation of China(Nos.81873835 and 82071726);the Suzhou Science and Technology Plan(No.SKY2022005);the Gusu Talent Project of Suzhou(No.GSWS2020011);the Science and Technology Project of Suzhou(No.SKY2023138);the research fund of the Second Affiliated Hospital of Soochow University(No.SDFEYGZ2319).

摘　　要：Uterine infertility is a major global issue causing substantial physical and psychological hardship for individuals struggling to conceive,while endometrium injury is one of the crucial factors causing infertility.Here,we demonstrate that platelet-derived extracellular vesicles(PEVs)have excellent regenerative ability in treating endometrial injuries,facilitating endometrium regeneration and resulting in a highly efficient live birth rate in the endometrium-injured murine model.We further investigated the underlying mechanisms by which PEVs affect the endometrium,showing their ability to promote neovascularization and suppress fibrosis.More importantly,the regenerative endometrium is more receptive to embrace the embryo,which can sustain the normal pregnancy.Our finding serves as a foundational basis for advancing the clinical translation of platelet-rich plasma(PRP)and therapies for endometrial regeneration.

关 键 词：endometrium regeneration fertility restoration platelet-derived extracellular vesicles platelet-rich plasma 

分 类 号：H31[语言文字—英语]