以百合病理论探讨干燥综合征合并焦虑抑郁的相关因素分析  

Analysis of Related Factors in Sjogren's Syndrome Complicated with Anxiety and Depression Based on Baihe Disease Theory

作　　者：单雪燕 周新尧[1] 何加乐 郭子琳 刘瑞华[1] 刘文靖 杨可非 姜泉[1] 唐晓颇[1] SHAN Xueyan;ZHOU Xinyao;HE Jiale;GUO Zilin;LIU Ruihua;LIU Wenjing;YANG Kefei;JIANG Quan;TANG Xiaopo(Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京中医药大学,北京100029

出　　处：《中国中医基础医学杂志》2025年第2期241-246,共6页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：中国中医科学院科技创新工程项目(CI2021A01502,CI2021A01510);临床科研一体化人才专项(创新团队培育项目)(HLCMHPP2023002);国家自然科学基金面上项目(82374285);中央级公益性科研院所基本科研业务费专项(ZZ15-XY-PT-11,ZZ15-YQ-023);中央高水平中医医院临床研究和成果转化能力提升项目——中医药临床循证研究专项(HLCMHPP2023087)。

摘　　要：目的分析干燥综合征(Sjogren's syndrome,SS)患者的抑郁、焦虑症状与中医证型、临床特征及实验室指标之间的相关性,为临床提供参考。方法采用横断面研究设计,纳入2023年5月至12月在中国30家大型三级甲等医院确诊为SS的患者共174例。收集患者的临床信息,并对其进行描述性统计,总结患者的证候特征;采用多因素回归分析方法,探讨SS患者抑郁、焦虑情绪的相关因素。结果阴虚津亏证与气阴两虚证SS患者在医院焦虑和抑郁量表(HADS)的焦虑域和抑郁域评分显著高于其他证型(P<0.05)。多因素Logistic回归分析表明,睡眠障碍、口腔溃疡是SS患者焦虑的独立影响因素,而血红细胞水平降低、睡眠障碍则是SS患者抑郁的独立影响因素。此外,与非焦虑和抑郁患者比较,焦虑和抑郁患者的生活质量下降、疲劳水平显著增加(P<0.05)。结论SS患者睡眠障碍、口腔溃疡和红细胞计数减少可能提示患者伴随焦虑、抑郁现象,这与百合病表现密切相关。本研究结果可为SS患者的心理应激管理提供新的理论依据和治疗思路。Objective To analyze the relationship between depression and anxiety in Sjogren's syndrome(SS)and traditional Chinese medicine syndromes,clinical characteristics,and laboratory indicators,providing a reference for clinical practice.Methods This cross-sectional study selected patients diagnosed with SS at 30 major tertiary hospitals in China from May to December,2023.A total of 174 complete questionnaires were collected.Descriptive statistics were used to summarize the syndrome characteristics of the patients.Multiple regression analysis was conducted to identify factors related to depression and anxiety in these patients.Results SS patients with Yin deficiency and fluid deficiency syndrome and Qi Yin deficiency syndrome had significantly higher scores in the anxiety and depression domains of the Hospital Anxiety and Depression Scale(HADS)compared to other syndrome types(P<0.05).Multivariate logistic regression analysis showed that sleep disturbances,and oral ulcers were independent factors associated with anxiety in SS patients,while decreased red blood cell levels and sleep disturbances were independent factors associated with depression.Additionally,the quality of life and fatigue perception in anxious and depressed patients were significantly worse than in those without anxiety or depression(P<0.05).Conclusion The presence of sleep disturbances,oral ulcers,and reduced red blood cell levels in SS patients may indicate the coexistence of anxiety and depression,closely aligning with the manifestations of Baihe disease.This connection could provide new theoretical foundations and treatment approaches for managing psychological stress in SS patients.

关 键 词：干燥综合征 中医证型 焦虑 抑郁 百合病 

分 类 号：R259[医药卫生—中西医结合]