重构本草——苦参  

Reconstruction of Chinese Materia Medica-lightyellow sophora root

作　　者：宋攀[1] 刘莹莹[2] 曾魏 何莉莎 SONG Pan;LIU Yingying;ZENG Wei;HE Lisha(Chengdu Integrated TCM and Western Medicine Hospital,Chengdu 610041,China;Chaoyang District Hospital of Traditional Chinese Medicine,Beijing 100020,China;Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China)

机构地区：[1]成都市中西医结合医院,成都610041 [2]北京市朝阳区中医医院,北京100020 [3]成都中医药大学,成都611137 [4]成都中医药大学附属医院,成都610072

出　　处：《长春中医药大学学报》2025年第2期132-135,共4页Journal of Changchun University of Chinese Medicine

基　　金：四川省科技厅青年基金(2023NSFSC1804);成都中医药大学“杏林学者”学科人才科研提升计划青基专项(QJRC2023003);成都中医药大学“杏林学者”学科人才科研提升计划(YYZX2021003);四川省哲学社会科学重点研究基地(扩展)中国出土医学文献与文物研究中心资助项目(CTWX2214)。

摘　　要：通过古籍文献调研、中药现代研究进展及其研究成果的梳理,结合中医临床及中药学等学科领域内专家学者的认识及应用经验,经讨论认为苦参:功效主要为清热燥湿,杀虫,利尿。症靶为瘙痒、腹泻、小便不利。标靶为抑菌杀虫、心律失常。现代药理发现,苦参及其有效成分具有抗病毒、保护心脏、抗肿瘤、抗菌、抗炎、降血糖、抗乙肝病毒、升高白细胞等作用。本品有一定的肝毒性,且脾胃虚寒者忌用,不宜与藜芦同用。临床使用剂量为6~30 g,当临床使用剂量超过30 g时应当少量频服,同时谨慎配伍护胃中药;内服时当根据不同疾病,或同一疾病的不同阶段进行辨证使用,并积极探索苦参用量与症靶、标靶的量效关系构建。Through investigation of ancient books and the sorting of modern research achievements of traditional Chinese medicine,combined with the understanding and application experience of experts and scholars in desciplinaryfields such as traditional Chinese medicine clinical medicine and science of Chinese materia medica,it is concluded that lightyellow sophora root mainly has the effects of clearing heat and removing dampness,klilling insects,and diuresis.The symptom targets are itching,diarrhea,and difficulty urinating.The biochemical indicator targets are antibacterial and insecticidal,and arrhythmia.Modern pharmacological studies have found that lightyellow sophora root and its active ingredients have effects of anti-virus,heart protection,anti-tumor,anti-bacterial,anti-inflammatory,hypoglycemia,anti hepatitis B virus,and increasing white blood cells.This product has certain hepatotoxicity and should not be used for those with deficient cold of spleen and stomach.It should not be used together with veratrum.The clinical dosage is 6-30g.When the clinical dosage exceeds 30g,it should be taken frequently in small amounts,and caution should be exercised when combining traditional Chinese medicine for stomach protection;When taken orally,it should be used based on syndrome differentiation according to different diseases or different stages of the same disease,and the construction of dose-effect relationship between the dosage of lightyellow sophora root and the symptom target and biochemical indicator target should be explored actively.

关 键 词：苦参 症靶 标靶 重构本草 临床回归 

分 类 号：R282[医药卫生—中药学]