扶正益气汤对浆细胞性乳腺炎肿块期患者血清SP、DA、PRL、CCL-18水平、免疫球蛋白的影响  

Effect of Fuzheng Yiqi decoction on serum levels of SP substance,dopamine,prolactin,chemokine(C-C motif)ligand 18 and immunoglobulin in patients with plasma cell mastitis in the mass stage

作　　者：李楠 谷盛莲 张竞飞[2] LI Nan;GU Shenglian;ZHANG Jingfei(Hegang People's Hospital,Hegang 154000,China;The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)

机构地区：[1]鹤岗市人民医院,黑龙江鹤岗154000 [2]黑龙江中医药大学附属第一医院,哈尔滨150040

出　　处：《长春中医药大学学报》2025年第2期177-181,共5页Journal of Changchun University of Chinese Medicine

摘　　要：目的探讨扶正益气汤对浆细胞性乳腺炎(PCM)肿块期患者血清SP、多巴胺(DA)、泌乳素(PRL)、趋化因子配体(CCL-18)水平、免疫球蛋白的影响。方法选择浆细胞性乳腺炎肿块期患者106例,按随机数表法分为对照组与观察组,各53例。对照组采用西药治疗,观察组在对照组基础上加用扶正益气汤治疗,2组均治疗28 d,随访9个月。比较2组临床疗效结果,比较2组治疗前后中医证候积分、血清SP、DA、PRL、CCL-18、免疫球蛋白水平变化情况,比较2组随访期间不良反应及复发情况。结果观察组临床疗效总有效率(96.23%,51/53)高于对照组(83.02%,44/53)(P<0.05)。2组治疗后肿块、红肿、脓肿、瘘管、疼痛评分及血清SP、PRL、CCL-18、免疫球蛋白水平均低于治疗前(P<0.05),观察组低于对照组(P<0.05);2组血清DA水平均升高(P<0.05),观察组高于对照组(P<0.05)。2组治疗期间均未发生发热、头晕头痛及胃肠道反应等不良反应。观察组随访6个月、9个月后复发率低于对照组(P<0.05)。结论扶正益气汤可有效改善浆细胞性乳腺炎肿块期患者中医证候,调节患者血清SP、DA、PRL、CCL-18、免疫球蛋白水平,可减轻患者疼痛,改善患者机体炎症及免疫功能,提高临床疗效,减少复发,且安全性良好。Objective To investigate the effect of Fuzheng Yiqi decoction on serum levels of SP substance,dopamine(DA),prolactin(PRL),chemokine(C-C motif)ligand 18(CCL-18),and immunoglobulin in patients with plasma cell mastitis(PCM)in the mass stage.Methods A total of 106 patients with PCM in the mass stage were selected and divided into the control group and the observation group according to random number table method,with 53 cases in each goup.The control group was treated with Western medicine,while the observation group was treated with Fuzheng Yiqi decoction on the basis of the treatment of the control group.Both groups were treated for 28 days and followed up for 9 months.The clinical efficacy of two groups was compared.The changes of traditional Chinese medicine(TCM)syndrome scores,serum SP,DA,PRL,CCL-18 and immunoglobulin levels before and after treatment between two groups were compared.The incidence of adverse reactions and recurrence between two groups during follow-up were compared.Results The total effective rate in the observation group(96.23%,51/53)was higher than that in the control group(83.02%,44/53)(P<0.05).After treatment,the masses,redness,swelling,abscesses,fistulas,pain scores,and the levels of serum SP,PRL,CCL-18,and immunoglobulin were all lower than before treatment(P<0.05),and the observation group was lower than the control group(P<0.05);The serum DA level in both groups increased(P<0.05),and the observation group was higher than the control group(P<0.05).During the treatment,no adverse reactions such as fever,dizziness,headache,or gastrointestinal reactions occurred in both groups.The recurrence rate of the observation group was lower than that of the control group after 6 and 9 months of follow-up(P<0.05).Conclusion Fuzheng Yiqi decoction can effectively improve TCM syndrome of patients with PCM in the mass stage,regulate the levels of serum SP,DA,PRL,CCL-18,and immunoglobulin,alleviate pain,improve inflammation and immune function,enhance clinical efficacy,and reduce the recurrence.This ther

关 键 词：浆细胞性乳腺炎 肿块期 扶正益气汤 SP物质 多巴胺 泌乳素 趋化因子配体18 免疫球蛋白 

分 类 号：R271.9[医药卫生—中西医结合]