组蛋白去乙酰化酶3在糖尿病及其并发症中的作用及其抑制剂的研究进展  

The role of histone deacetylase 3 in diabetes and its complications,and the research progress on histone deacetylase 3 inhibitors

作　　者：翟佳羽 冯存玉 高雪峰 雷丽冉 雷蕾 环奕 ZHAI Jia-yu;FENG Cun-yu;GAO Xue-feng;LEI Li-ran;LEI Lei;HUAN Yi(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]中国医学科学院、北京协和医学院药物研究所,天然药物活性物质与功能国家重点实验室,北京100050

出　　处：《药学学报》2025年第1期1-11,共11页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金青年科学基金项目(82200883);中国医学科学院创新工程项目(2022-I2M-2-002)。

摘　　要：组蛋白去乙酰化酶3(histone deacetylase 3,HDAC3)是一种表观遗传修饰酶,在糖尿病及其并发症的发生与发展中发挥重要作用。研究报道,在1型糖尿病中,HDAC3活性增加与胰岛β细胞功能障碍有关;而在2型糖尿病中,HDAC3通过调控肝脏、脂肪和肌肉组织的代谢,影响胰岛素抵抗和信号转导。此外,HDAC3在糖尿病心肌病、视网膜病变和肾病等并发症中扮演了关键角色。通过选择性抑制HDAC3,可以改善胰岛素敏感性并减轻慢性炎性,改善胰岛细胞功能,有望成为糖尿病及其并发症治疗的新策略。Histone deacetylase 3(HDAC3)is an epigenetic modification enzyme that plays a crucial role in the development and progression of diabetes and its complications.Studies have reported that increased HDAC3 activity is associated with pancreaticβ-cell dysfunction in type 1 diabetes,while in type 2 diabetes,HDAC3 affects insulin resistance and signaling by regulating the metabolism of the liver,adipose tissue,and muscle.Additionally,HDAC3 plays a key role in diabetic complications such as cardiomyopathy,retinopathy,and nephropathy.Selective inhibition of HDAC3 has the potential to improve insulin sensitivity,reduce chronic inflammation,and enhance pancreatic cell function,offering a promising new therapeutic strategy for diabetes and its complications.

关 键 词：组蛋白去乙酰化酶3 糖尿病 糖尿病并发症 胰岛素抵抗 胰岛Β细胞 

分 类 号：R966[医药卫生—药理学]