迷迭香酸在心血管疾病防治中的作用机制研究进展  

Research progress on the mechanism of action of rosmarinic acid in the prevention of cardiovascular diseases

作　　者：蔡珂 黄圣如 高芳芳 彭修娟[2] 郭盛[1] 刘峰[2] 段金廒[1] 宿树兰[1] CAI Ke;HUANG Sheng-ru;GAO Fang-fang;PENG Xiu-juan;GUO Sheng;LIU Feng;DUAN Jin-ao;SU Shu-lan(Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,Jiangsu Key Laboratory for High Technology Research of TCM Formulae,National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China;Shaanxi Institute of International Trade&Commerce,Xianyang 710061,China)

机构地区：[1]南京中医药大学,江苏省中药资源产业化过程协同创新中心,江苏省方剂高技术研究重点实验室,中药资源产业化与方剂创新药物国家地方联合工程研究中心,江苏南京210023 [2]陕西国际商贸学院,陕西咸阳710061

出　　处：《药学学报》2025年第1期12-21,共10页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金项目(81673533,82274086);国家自然科学基金区域创新发展联合基金重点支持项目(U23A20502);国家中医药管理局高水平中医药重点学科建设项目(ZYYZDXK-2023083);国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-D-202005)。

摘　　要：随着社会经济的飞速发展和人类生活水平的持续提高,心血管疾病(cardiovascular disease,CVD)的发病率、致死率及复发率逐年上升,严重影响着人们的生命健康。常规的治疗药物对致残率的改善有限,因此,寻求新的治疗药物及作用靶点成为目前研究的热点之一。近年来,天然化合物迷迭香酸(rosmarinic acid,RA)在CVD的治疗作用备受关注,其能够通过调控多条信号通路防治CVD,发挥抗氧化、抗细胞凋亡、抗炎、抗血小板聚集以及抗凝血、保护内皮功能等生理活性。本文系统梳理了RA在CVD防治中的作用,对其作用机制进行归纳分析,以期为深入挖掘RA在CVD中防治价值及进一步开发成为防治药物提供科学依据和重要支撑。With the rapid development of social economy and the continuous improvement of human living standard,the incidence,fatality and recurrence rates of cardiovascular disease(CVD)are increasing year by year,which seriously affects people's life and health.Conventional therapeutic drugs have limited improvement on the disability rate,so the search for new therapeutic drugs and action targets has become one of the hotspots of current research.In recent years,the therapeutic role of the natural compound rosmarinic acid(RA)in CVD has attracted much attention,which is capable of preventing CVD by modulating multiple signalling pathways and exerting physiological activities such as antioxidant,anti-apoptotic,anti-inflammatory,anti-platelet aggregation,as well as anti-coagulation and endothelial function protection.In this paper,the role of RA in the prevention of CVD is systematically sorted out,and its mechanism of action is summarised and analysed,with a view to providing a scientific basis and important support for the in-depth exploration of the prevention value of RA in CVD and its further development as a prevention drug.

关 键 词：迷迭香酸 心血管 抗炎 抗氧化 抗血小板聚集 抗凝血 保护内皮功能 

分 类 号：R966[医药卫生—药理学]